NDLI: L-Arginine improves multiple physiological parameters in mice exposed to diet-induced metabolic disturbances

Content Provider	Springer Nature Link
Author	Clemmensen, Christoffer Madsen, Andreas N. Smajilovic, Sanela Holst, Birgitte Bräuner Osborne, Hans
Copyright Year	2011
Abstract	l-Arginine (l-Arg) is a conditionally essential amino acid and a natural constituent of dietary proteins. Studies in obese rats and type 2 diabetic humans have indicated that dietary supplementation with l-Arg can diminish gain in white adipose tissue (WAT) and improve insulin sensitivity. However, the effects of l-Arg on glucose homeostasis, body composition and energy metabolism remain unclear. In addition, no studies have, to our knowledge, examined whether l-Arg has beneficial effects as a dietary supplement in the mouse model. In the present study, we investigated the effects of l-Arg supplementation to male C57BL/6 mice on an array of physiological parameters. l-Arg supplemented mice were maintained on a low-protein diet and body composition, appetite regulation, glucose tolerance, insulin sensitivity and energy expenditure were evaluated. A significant reduction in epididymal WAT was observed in l-Arg supplemented mice compared with mice fed an isocaloric control diet. Surprisingly, the l-Arg supplemented animals were hyperphagic corresponding to a highly significant decrease in feed efficiency, as body weight developed in a similar pattern in both experimental groups. Glucose homeostasis experiments revealed a major effect of l-Arg supplementation on glucose tolerance and insulin sensitivity, interestingly, independent of a parallel regulation in whole-body adiposity. Increased l-Arg ingestion also raised energy expenditure; however, no concurrent effect on locomotor activity, substrate metabolism or expression of uncoupling proteins (UCP1 and UCP2) in adipose tissues was displayed. In conclusion, dietary l-Arg supplementation substantially affects an array of metabolic-associated parameters including a reduction in WAT, hyperphagia, improved insulin sensitivity and increased energy expenditure in mice fed a low-protein diet.
Starting Page	1265
Ending Page	1275
Page Count	11
File Format	PDF
ISSN	09394451
Journal	Amino Acids
Volume Number	43
Issue Number	3
e-ISSN	14382199
Language	English
Publisher	Springer Vienna
Publisher Date	2011-12-27
Publisher Place	Vienna
Access Restriction	Subscribed
Subject Keyword	l-Arginine Diet Amino acids Low protein Insulin sensitivity Obesity Diabetes Life Sciences Analytical Chemistry Biochemistry Proteomics Neurobiology Biochemical Engineering
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Clinical Biochemistry

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