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| Content Provider | Springer Nature Link |
|---|---|
| Author | Panda, Gourisankar Selim, Md. Pal, Rupali Mukherjea, Kalyan K. |
| Copyright Year | 2008 |
| Abstract | The interaction of cobalt(II)-glutathione (CoGSH) with deoxyribonucleic acid (DNA) has been studied by UV–vis, fluorescence, circular dichroism (CD), thin-film infrared (IR), and viscometric techniques. From the UV-spectroscopic method, binding constant (K b) was determined and was found to be 2.3 × 106 M−1. In fluorimetric analysis, the quenching of fluorescence intensity of DNA bound to ethidium bromide (EB) was investigated. The Stern–Volmer quenching constant (K sv) was also estimated from this study and was found to be 2.8 × 106 M−1at 37 °C. The solution CD spectra of DNA and DNA–CoGSH indicate that in each case, DNA exists in the ‘B’ conformation and suggested an intercalative binding mode. Thin-film IR data also reveal that DNA attains the ‘B’ family of conformations after interaction with CoGSH complex. The increase in DNA viscosity in the presence of CoGSH complexes is attributed to the lengthening of DNA helix due to intercalation.The spectrophotometric, CD, thin film IR, viscometric and fluorimetric studies on the interaction of CoGSH with DNA indicated an intercalative binding mode with the retention of ‘B’ conformation of DNA. |
| Starting Page | 281 |
| Ending Page | 286 |
| Page Count | 6 |
| File Format | |
| ISSN | 00269247 |
| Journal | Monatshefte für Chemie - Chemical Monthly |
| Volume Number | 140 |
| Issue Number | 3 |
| e-ISSN | 14344475 |
| Language | English |
| Publisher | Springer Vienna |
| Publisher Date | 2008-09-20 |
| Publisher Place | Vienna |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Calf thymus DNA Glutathione Electronic absorption spectra Circular dichroism (CD) Intercalation Fluorescence quenching Viscometric studies Theoretical and Computational Chemistry Physical Chemistry Organic Chemistry Inorganic Chemistry Analytical Chemistry Chemistry/Food Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry |
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