NDLI: Expression of HIV-encoded microRNA-TAR and its inhibitory effect on viral replication in human primary macrophages

Content Provider	Springer Nature Link
Author	Li, Li Feng, Haimin Da, Qin Jiang, Honglin Chen, Lang Xie, Linlin Huang, Qiuling Xiong, Hairong Luo, Fan Kang, Lei Zeng, Yan Hu, Haitao Hou, Wei Feng, Yong
Copyright Year	2016
Abstract	A number of virus-encoded microRNAs have been shown to play important roles in virus replication and virus-host interactions, although the expression and function of miR-TAR-3p derived from the human immunodeficiency virus type 1 (HIV-1) TAR element remain controversial. In this study, miR-TAR-3p was detected in human peripheral blood monocyte-derived macrophages (MDMs) infected by HIV-1. Overexpression of miR-TAR-3p impaired viral replication, while inhibition of miR-TAR-3p enhanced it. Additionally, miR-TAR-3p repressed viral transcription and replication by targeting the TAR element in the HIV-1 5’-LTR in a sequence-specific manner. These results confirm the presence of miR-TAR-3p in HIV-1-infected MDMs and suggest that its function might be used as a mechanism to modulate HIV-1 replication through the expression of a negative regulatory factor.
Starting Page	1115
Ending Page	1123
Page Count	9
File Format	PDF
ISSN	03048608
Journal	Archives of Virology
Volume Number	161
Issue Number	5
e-ISSN	14328798
Language	English
Publisher	Springer Vienna
Publisher Date	2016-01-30
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Virology Medical Microbiology Infectious Diseases
Content Type	Text
Resource Type	Article
Subject	Virology Medicine

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Expression of HIV-encoded microRNA-TAR and its inhibitory effect on viral replication in human primary macrophages