NDLI: Influenza A virus infection modulates the expression of type IV collagenase in epithelial cells

Content Provider	Springer Nature Link
Author	Yeo, S. J. Kim, S. J. Kim, J. H. Lee, H. J. Kook, Y. H.
Copyright Year	1999
Abstract	We investigated the effect of influenza A/Beijing/353/89 (H3N2) virus infection on the expression of type IV collagenase in two different types of epithelial cell. Depending on the cell line infected, the viral infection caused changes in the expression of type IV collagenase. The expression of matrix metalloproteinase-9 (MMP-9; 92 kDa) but not of matrix metalloproteinase-2 (MMP-2; 72 kDa) was stimulated in Vero cells. In MDCK cells, the MMP-2 production increased with the virus infection. According to the enzymatic activity revealed with zymography, the MMP-9 promoter activity rose by a factor of over 1788 in influenza A virus-infected Vero cells but not in MDCK cells. The tissue inhibitor of metalloproteinase, TIMP-1, had increased slightly (2.3-fold) in Vero cells 48 hours after the infection, but in MDCK cells, influenza A virus had no effect on the TIMP-1 expression. In conclusion, the MMP-9 and -2 expression by influenza A virus infecton are modulated at transcriptional level, depending on the epithelial cell line.
Starting Page	1361
Ending Page	1370
Page Count	10
File Format	PDF
ISSN	03048608
Journal	Archives of Virology
Volume Number	144
Issue Number	7
e-ISSN	14328798
Language	English
Publisher	Springer-Verlag
Publisher Date	2014-05-20
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Virology Medical Microbiology Infectious Diseases
Content Type	Text
Resource Type	Article
Subject	Virology Medicine

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