NDLI: Poor induction of interferon-induced 2′,5′-oligoadenylate synthetase (2–5 AS) in cells persistently infected with mumps virus is caused by decrease of STAT-1α

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Poor induction of interferon-induced 2′,5′-oligoadenylate synthetase (2–5 AS) in cells persistently infected with mumps virus is caused by decrease of STAT-1α

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Archives of Virology : Volume 142

Poor induction of interferon-induced 2′,5′-oligoadenylate synthetase (2–5 AS) in cells persistently infected with mumps virus is caused by decrease of STAT-1α

Content Provider	Springer Nature Link
Author	Yokosawa, N. Kubota, T. Fujii, N.
Copyright Year	1998
Abstract	Poor induction of interferon-induced 2′,5′-oligoadenylate synthetase (2-5AS) has been demonstrated in cells persistently infected with mumps virus as compared with uninfected cells. As for the number of interferon (IFN) receptors and the level of IFN regulatory factors (IRF-1 and IRF-2) mRNAs, there was little difference between them. Therefore, it is suggested that the IFN-α signaling system is ineffective in the persistently infected cells. Components of IFN-stimulating gene factor 3α (ISGF-3α), STAT-1α (p91) and STAT-2 (p113), were investigated in human amnion (FL), human nasopharyngeal cancer (KB), human T-lymphoid (HUT 78), and human B-lymphoid (Akata) cells persistently infected with mumps virus. STAT-1α, but not STAT-2, disappeared in these persistently infected cells, and this factor was not restored by treatment of these cells with IFN. However, no difference was observed between the levels of STAT-1α mRNA transcript in persistently infected and uninfected control cells. It is reason- able to infer that the poor induction of 2-5AS activity is due to the decrease of STAT-1α in correlation with the IFN-signal transduction pathway. Furthermore, induction of other IFN-stimulated genes (ds-RNA activated protein kinase, PKR, and MxA protein) was also reduced in the cells persistently infected with mumps virus.
Starting Page	1985
Ending Page	1992
Page Count	8
File Format	PDF
ISSN	03048608
Journal	Archives of Virology
Volume Number	143
Issue Number	10
e-ISSN	14328798
Language	English
Publisher	Springer-Verlag
Publisher Date	2014-04-08
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Virology Medical Microbiology Infectious Diseases
Content Type	Text
Resource Type	Article
Subject	Virology Medicine

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Investigation of IFN Type-I Receptor and IFN Regulatory Factor Expression Relating to Induction of 2', 5'-Oligoadenylate Synthetase in Cells Persistently Infected with the Mumps Virus

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Poor induction of interferon-induced 2′,5′-oligoadenylate synthetase (2–5 AS) in cells persistently infected with mumps virus is caused by decrease of STAT-1α

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Poor induction of interferon-induced 2′,5′-oligoadenylate synthetase (2–5 AS) in cells persistently infected with mumps virus is caused by decrease of STAT-1α