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Decrease of interferon-induced 2',5'-oligoadenylate synthetase activity in cirrhotic rat liver.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Miyajima, Ichiro Sata, Michio Uchimura, Yasuyo Suzuki, Hiroshi Tanikawa, Kyuichi |
| Copyright Year | 1995 |
| Abstract | We evaluated the effect of hepatic fibrosis on the induction of hepatic 2',5'-oligoadenylate synthetase (2-5AS) by interferon (IFN) in a rat model of liver cirrhosis, induced with thioacetamide. Although there was no difference in serum 2-5AS activity between the control and cirrhotic rats given murine IFN, 2-5AS activity in the liver homogenates of cirrhotic rats was significantly lower than in the controls (105 +/- 18.5 vs. 171 +/- 10.2 pmol/micrograms, p < 0.01). These results suggested that hepatic fibrosis attenuated the effect of IFN and one of the reasons for this may be the decreased induction of hepatic 2-5AS activity after IFN administration in the presence of a cirrhotic liver. |
| File Format | PDF HTM / HTML |
| DOI | 10.11150/kansenshogakuzasshi1970.69.1383 |
| PubMed reference number | 8586891 |
| Journal | Medline |
| Volume Number | 69 |
| Issue Number | 12 |
| Alternate Webpage(s) | https://www.jstage.jst.go.jp/article/kansenshogakuzasshi1970/69/12/69_12_1383/_pdf |
| Alternate Webpage(s) | https://doi.org/10.11150/kansenshogakuzasshi1970.69.1383 |
| Journal | Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |