NDLI: Molecular epidemiology of coxsackievirus type B1

Content Provider	Springer Nature Link
Author	Abdelkhalek, Ichrak Seghier, Mohamed Yahia, Ahlem Ben Touzi, Henda Meddeb, Zina Triki, Henda Rezig, Dorra
Copyright Year	2015
Abstract	Coxsackievirus type B1 (CVB1) has emerged globally as the predominant enterovirus serotype and is associated with epidemics of meningitis and chronic diseases. In this report, the phylogeny of CVB1 was studied based on the VP1 sequences of 11 North African isolates and 81 published sequences. All CVB1 isolates segregated into four distinct genogroups and 10 genotypes. Most of the identified genotypes of circulating CVB1 strains appear to have a strict geographical specificity. The North African strains were of a single genotype and probably evolved distinctly. Using a relaxed molecular clock model and three different population models (constant population, exponential growth and Bayesian skyline demographic models) in coalescent analysis using the BEAST program, the substitution rate in CVB1 varied between 6.95 × 10−3 and 7.37 × 10−3 substitutions/site/year in the VP1 region. This study permits better identification of circulating CVB1, which has become one of the most predominant enterovirus serotypes in humans.
Starting Page	2815
Ending Page	2821
Page Count	7
File Format	PDF
ISSN	03048608
Journal	Archives of Virology
Volume Number	160
Issue Number	11
e-ISSN	14328798
Language	English
Publisher	Springer Vienna
Publisher Date	2015-08-05
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Enteroviruses Coxsackievirus type B1 Phylogeny VP1 gene Virology Medical Microbiology Infectious Diseases
Content Type	Text
Resource Type	Article
Subject	Virology Medicine

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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