NDLI: Mouse Mx2 protein inhibits hantavirus but not influenza virus replication

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Mouse Mx2 protein inhibits hantavirus but not influenza virus replication

Content Provider	Springer Nature Link
Author	Jin, H. K. Yoshimatsu, K. Takada, A. Ogi, M. Asa, A. Arikawa, J. Watanabe, T.
Copyright Year	2001
Abstract	The antiviral potential of Mx2 protein remains unknown, because the Mx2 gene in commonly used strains of laboratory mice is nonfunctional. Our previous study showed that functional Mx2 protein in some feral-origin strains was induced upon interferon treatment, was localized in the cytoplasm, and inhibited vesicular stomatitis virus replication. In the present study, we have demonstrated that the embryonic fibroblastic cells from a feral-origin strain (SPR) expressed 74 kDa Mx2 protein, which prevented the accumulation of viral transcripts and proteins of hantaviruses when the Mx2 gene was constitutively expressed in transfected Vero cells. Furthermore, the cells showed significantly lower titers of the virus than control cells. In contrast, influenza virus replication was not affected by the expression of Mx2 protein in the Vero cells.
Starting Page	41
Ending Page	49
Page Count	9
File Format	PDF
ISSN	03048608
Journal	Archives of Virology
Volume Number	146
Issue Number	1
e-ISSN	14328798
Language	English
Publisher	Springer-Verlag
Publisher Date	2001-01-31
Publisher Place	Wien
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Virology Medicine

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