NDLI: Ultrasensitive detection of Dynabeads protein A using the giant magnetoimpedance effect

Content Provider	Springer Nature Link
Author	Wang, Tao Zhou, Yong Lei, Chong Lei, Jian Yang, Zhen
Copyright Year	2013
Abstract	We report on a biosensing system for ultrasensitive detection of Dynabeads protein A (DPA) that employs the magnetoimpedance (GMI) effect. The system is capable of detecting DPA via magnetic signals in the form of a magnetoimpedance change. The GMI ratio shows distinctive changes because of the induced fringe field produced by the superparamagnetic Dynabeads. The GMI ratio undergoes an overall downturn at high frequencies, but the drop becomes smaller with increasing DPA concentration. This phenomenon has not been observed so far. At a concentration of 0.1 μg mL−1, the GMI ratio drops by 8.53 % at a frequency of 1.4 MHz. In other word: almost 90 Dynabeads can be detected. We believe that this novel scheme has a large potential in high-sensitivity and miniaturized immunoassays. Figure The GMI biosensing system is established for ultrasensitive detection of Dynabeads protein A. The rectangle nano-Au film is used for immobilization of the Dynabeads protein A. The longitudinal external field (He) is generated by a DC field source (0–125 Oe). The GMI biosensor is driven by AC with an amplitude of 10 mA (0.1–5 MHz).
Starting Page	1211
Ending Page	1216
Page Count	6
File Format	PDF
ISSN	00263672
Journal	Microchimica Acta
Volume Number	180
Issue Number	13-14
e-ISSN	14365073
Language	English
Publisher	Springer Vienna
Publisher Date	2013-07-05
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Dynabeads protein A Ultrasensitive detection Giant magnetoimpedance ratio Drop Flexible biosensing system Superparamagnetic Nanochemistry Nanotechnology Characterization and Evaluation of Materials Analytical Chemistry Microengineering
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry

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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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