NDLI: Logic gates based on G-quadruplexes: principles and sensor applications

Content Provider	Springer Nature Link
Author	Guo, Yahui Yao, Weirong Xie, Yunfei Zhou, Xiaodong Hu, Jiming Pei, Renjun
Copyright Year	2015
Abstract	This review (with 139 refs.) gives a fundamental introduction into the sensors and logic gates based on G-quadruplexes (G4s). G4 characterizes vibrant binding activities and topology diversity, which contribute to the multiple signal output modes (including labeled moieties based on distance changes, label-free outputs by employing fluorescent ligands, G4/hemin DNAzyme with catalyzing activity and colorimetric readout using gold nanoparticles) and versatile design strategies (including target-induced G4 formation/disruption, liberation of blocked G4, split G4 probes, polymerase-assisted amplification and G4/hemin enrichment on sensor surface) of G4s-based methods. Following two important trends in logic gates (application of intelligent detection schemes and logic circuit constructions), specific sections review logic sensors and logic circuits based on G4s with several representative examples. We close this review with conclusions and give a perspective that employment of DNA technologies (such as aptamers, DNA junctions/origami, toehold-mediated strand displacement, enzyme-assisted amplification, metal ion-dependent DNAzymes) and various nanomaterials in G4s-based methods results in quite a large potential in terms of logic detection and construction of logic circuits. Graphical Abstract The vibrant binding activities, different structural topologies, multiple signal output modes and a variety of designing strategies contribute to the versatile roles of G-quadruplexes in the application and development of DNA logic gates and logic circuits.
Starting Page	21
Ending Page	34
Page Count	14
File Format	PDF
ISSN	00263672
Journal	Microchimica Acta
Volume Number	183
Issue Number	1
e-ISSN	14365073
Language	English
Publisher	Springer Vienna
Publisher Date	2015-09-12
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Logic circuit Aptamer Origami DNAzyme Enzyme-assisted amplification DNA computation Guanine-rich sequences G4-binding dyes Nanochemistry Nanotechnology Characterization and Evaluation of Materials Analytical Chemistry Microengineering
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry

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