NDLI: A microchannel neural interface with embedded microwires targeting the peripheral nervous system

Content Provider	Springer Nature Link
Author	Kim, Bongkyun Reyes, Alejandro Garza, Bernardo Choi, Yoonsu
Copyright Year	2014
Abstract	The essential purpose of neural interfaces is to record and stimulate neural activity. Careful analysis of neural signals allows them to be used to control technologies such as prosthetics and muscle stimulators that restore lost functionality caused by injury. Designing interfaces advanced enough to restore full functionality, however, is a challenge. Presented here is an animal study using the Texas regenerative peripheral nerve interface (TxNI), a novel neural interface device for communicating with peripheral nerves. Small extracellular potentials and concentration of current at the nodes of Ranvier increases the complexity of recording from axons. The TxNI is designed to obtain weak neural signals which are difficult to acquire using other techniques. The TxNI combines a PDMS (polydimethylsiloxane) microchannel scaffold with microwires (used as recording electrodes) embedded within the microchannels. Axonal regeneration is confined to the microchannels and electrodes are long enough to record from the nodes of Ranvier. Although several types of electrodes for peripheral nerve interfaces have been reported, they typically record unwanted signals from surrounding musculature and are subject to crosstalk. To address this, neural regeneration is directed through the TxNI in sealed microfluidic channels. The TxNI was successfully implanted in the rat sciatic nerve in the animal facility at UTPA. The details regarding its fabrication and implantation are described here. The present result is to be used to evaluate the effectiveness of the TxNI for use in advanced prosthetics. In particular, it aims to be used in a noninvasive brain-machine interface for bidirectional prosthetic arms.
Starting Page	1551
Ending Page	1557
Page Count	7
File Format	PDF
ISSN	09467076
Journal	Microsystem Technologies
Volume Number	21
Issue Number	7
e-ISSN	14321858
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-10-14
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Electronics and Microelectronics, Instrumentation Nanotechnology Mechanical Engineering
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Condensed Matter Physics Electronic, Optical and Magnetic Materials Electrical and Electronic Engineering Hardware and Architecture

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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