NDLI: Modeling in vitro neural electrode interface in neural cell culture medium

Content Provider	Springer Nature Link
Author	Sun, Tao Tsang, Wei Mong Park, Woo Tae Cheng, Kangjian Merugu, Srinivas
Copyright Year	2014
Abstract	A stable neural interface between neural electrodes and surrounding tissues is a critical point to achieve long-term signal recording stability, and flexible polymer-based neural microelectrodes are attracting growing interests due to their mechanical properties compatible to surrounding tissues and potential to minimize post-implantation injury. As a fundamental study to have an insight into the flexible polymer-based microelectrode–tissue interface in vivo, the neural microelectrode interface was investigated in vitro in neural cell culture medium. Flexible polyimide-based gold electrodes used for recording neural signals were micro fabricated and packaged to model the in vitro neural microelectrode–cell medium interface. The surface of gold recording sites of the neural microelectrode was observed using scanning electron microscopy (SEM), and island-like structure with the size of 537.4 ± 357.2 nm was visualized. To better understand biological processes that affect neural signal recording, the microelectrodes were immersed in neural cell culture medium for 9 days, and electrochemical impedance spectroscopy (EIS) measurement was carried out at each time point. Nyquist and Bode plots resulting from the EIS measurement were analyzed by fitting the experimental data with equivalent circuit models. On the basis of equivalent circuit models, physical processes occurring at the interface were described. Moreover, the mechanism for the impedance variation of recording sites in cell culture medium was discussed.
Starting Page	1739
Ending Page	1747
Page Count	9
File Format	PDF
ISSN	09467076
Journal	Microsystem Technologies
Volume Number	21
Issue Number	8
e-ISSN	14321858
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-08-09
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Electronics and Microelectronics, Instrumentation Nanotechnology Mechanical Engineering
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Condensed Matter Physics Electronic, Optical and Magnetic Materials Electrical and Electronic Engineering Hardware and Architecture

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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