NDLI: Expression, mitogenic activity and regulation by growth hormone of growth hormone/insulin-like growth factor in Branchiostoma belcheri

Content Provider	Springer Nature Link
Author	Guo, Bin Zhang, Shicui Wang, Shaohui Liang, Yujun
Copyright Year	2009
Abstract	The growth hormone (GH)/insulin-like growth factor (IGF) axis is unique to all the vertebrate species but its evolutionary origin is ill-defined. We therefore cloned a cDNA encoding Branchiostoma belcheri IGF (BbIGF). BbIGF was expressed in a tissue-specific manner, with the most abundant expression in the hepatic caecum, the putative liver precursor. The recombinant BbIGF expressed in vitro showed mitogenic activity capable of stimulating cell proliferation in the flounder gill, a characteristic of vertebrate IGF. Quantitative real-time polymerase chain reaction demonstrated that the recombinant rat GH was able to induce a significant up-regulation of BbIGF expression in the hepatic caecum. Moreover, Western blotting revealed the presence of a molecule similar to rat GH receptor in the hepatic caecum. These results suggest that BbIGF expression is inducible by exogenous mammalian GH, suggesting the presence of a GH/IGF axis in B. belcheri. The relationship between BbIFG expression and the origin of the vertebrate liver is discussed.
Starting Page	67
Ending Page	77
Page Count	11
File Format	PDF
ISSN	0302766X
Journal	Cell and Tissue Research
Volume Number	338
Issue Number	1
e-ISSN	14320878
Language	English
Publisher	Springer-Verlag
Publisher Date	2009-08-06
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Growth hormone Insulin-like growth factor Hepatic caecum Amphioxus Lancelet Branchiostoma belcheri Molecular Medicine Proteomics Human Genetics
Content Type	Text
Resource Type	Article
Subject	Cell Biology Histology Pathology and Forensic Medicine

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