NDLI: Expression of insulin-like growth factor (IGF)-II in human prostate, breast, bladder, and paraganglioma tumors

Content Provider	Springer Nature Link
Author	Li, Shu Lian Goko, Hideki Xu, Zhao Dong Kimura, G. Sun, Yanyu Kawachi, Mark H. Wilson, Timothy G. Wilczynski, Sharon Fujita Yamaguchi, Y.
Copyright Year	1998
Abstract	Insulin-like growth factors (IGFs) are potent mitogens for a variety of cancer cells in vitro. A paracrine/autocrine role of IGF-II in the growth of breast and prostate cancer cells has been suggested. Information on cell-type-specific IGF-II expression in vivo in the breast and prostate is, however, limited. Thus, cell types expressing IGF-II mRNA and protein in tumors were identified by in situ hybridization and immunohistochemistry. Of 36 prostate, 17 breast, and 10 bladder cancers, and 9 paraganglioma tissues examined, IGF-II was expressed in more than 50% of prostate, breast, and bladder tumors, and in 100% of paraganglioma tumors. Expression levels of IGF-II were highest in the paraganglioma and bladder followed by prostate and breast tumors. In all the tumors expressing IGF-II, both mRNA and protein were localized to malignant cells, expression in the stroma being minimal. Since previous studies had indicated that an incompletely processed form of 15-kDa IGF-II exhibited higher mitogenic potency than the completely processed 7.5-kDa IGF-II form, the quantity and size of IGF-II proteins expressed in these tumors were analyzed by Western immunoblotting. Greater expression of 15-kDa IGF-II relative to the 7.5-kDa IGF-II form was clearly demonstrated in all six prostate cancers and in half of the two breast and four bladder cancers examined. The results are consistent with the hypothesis that the 15-kDa form of IGF-II expressed in cancerous cells contributes to autocrine cancer cell growth in vivo.
Starting Page	469
Ending Page	479
Page Count	11
File Format	PDF
ISSN	0302766X
Journal	Cell and Tissue Research
Volume Number	291
Issue Number	3
e-ISSN	14320878
Language	English
Publisher	Springer-Verlag
Publisher Date	1998-02-12
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Cell Biology Histology Pathology and Forensic Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Insulin-like growth factor receptor expression and function in human breast cancer. Cancer res (1990).

Expression of insulin-like growth factor II (IGF-II) and histological changes in the thymus and spleen of transgenic mice overexpressing IGF-II

Expression of the insulin-like growth factor receptor 1 during human embryogenesis.

Expression, mitogenic activity and regulation by growth hormone of growth hormone/insulin-like growth factor in Branchiostoma belcheri

Insulin-like growth factors 1 and 2 regulate expression of β-casein in vitro in mouse mammary epithelial cells

Expression of insulin-like growth factor II mRNA binding protein 3 (IMP3) in enchondroma and chondrosarcoma.

Receptors for Insulin-like Growth Factor (IGF)-II/cation-independent Mannose-6-phosphate Are Present in Mouse Neurons and Influenced by IGF-II Treatment

Insulin-like growth factor II mRNA expression in human breast cancer (1988)

Expression of Insulin-Like Growth Factors in the Placenta in Preeclampsia

Expression of insulin-like growth factor (IGF)-II in human prostate, breast, bladder, and paraganglioma tumors

Similar Documents

Insulin-like growth factor receptor expression and function in human breast cancer. Cancer res (1990).

Expression of insulin-like growth factor II (IGF-II) and histological changes in the thymus and spleen of transgenic mice overexpressing IGF-II

Expression of the insulin-like growth factor receptor 1 during human embryogenesis.

Expression, mitogenic activity and regulation by growth hormone of growth hormone/insulin-like growth factor in Branchiostoma belcheri

Insulin-like growth factors 1 and 2 regulate expression of β-casein in vitro in mouse mammary epithelial cells

Expression of insulin-like growth factor II mRNA binding protein 3 (IMP3) in enchondroma and chondrosarcoma.

Receptors for Insulin-like Growth Factor (IGF)-II/cation-independent Mannose-6-phosphate Are Present in Mouse Neurons and Influenced by IGF-II Treatment

Insulin-like growth factor II mRNA expression in human breast cancer (1988)

Expression of Insulin-Like Growth Factors in the Placenta in Preeclampsia

Expression of insulin-like growth factor (IGF)-II in human prostate, breast, bladder, and paraganglioma tumors