NDLI: Mitochondrial DNA polymorphisms associated with longevity in a Finnish population

Content Provider	Springer Nature Link
Author	Niemi, Anna Kaisa Hervonen, Antti Hurme, Mikko Karhunen, Pekka J. Jylhä, Marja Majamaa, Kari
Copyright Year	2002
Abstract	Sequence variation in mitochondrial DNA (mtDNA) may cause slight differences both in the functioning of the respiratory chain and in free radical production, and an association between certain mtDNA haplogroups and longevity has been suggested. In order to determine further the role of mtDNA in longevity, we studied the frequencies of mtDNA haplogroups and haplogroup clusters among elderly subjects and controls in a Finnish population. Samples were obtained from 225 persons aged 90–91 years (Vitality 90+) and from 400 middle-aged controls and 257 infants. MtDNA haplogroups were determined by restriction fragment length polymorphism. The haplogroup frequencies of the Vitality 90+ group differed from both those of the middle-aged controls (P=0.01) and the infants (P=0.00005), haplogroup H being less frequent than among the middle-aged subjects (P=0.001) and infants (P=0.00001), whereas haplogroups U and J were more frequent. Haplogroup clusters also differed between Vitality 90+ and both the middle-aged subjects (P=0.002) and infants (P=0.00001), the frequency of haplogroup cluster HV being lower in the former and that of UK and WIX being higher. These data suggest an association between certain mtDNA haplogroups or haplogroup clusters and longevity. Furthermore, our data appear to favour the presence of advantageous polymorphisms and support a role for mitochondria and mtDNA in the degenerative processes involved in ageing.
Starting Page	29
Ending Page	33
Page Count	5
File Format	PDF
ISSN	03406717
Journal	Human Genetics
Volume Number	112
Issue Number	1
e-ISSN	14321203
Language	English
Publisher	Springer-Verlag
Publisher Date	2002-10-17
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

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