NDLI: Three duplicons form a novel chimeric transcription unit in the pericentromeric region of chromosome 22q11

Content Provider	Springer Nature Link
Author	Bridgland, Lindsay Footz, Tim K. Kardel, Melanie D. Riazi, Ali M. McDermid, Heather E.
Copyright Year	2002
Abstract	Pericentromeric regions of human chromosomes are preferential sites for the integration of duplicated DNA, or "duplicons", which often contain gene fragments. Although pericentromeric regions appear to be genomic junkyards, they could also be the birthplace of new genes with novel functions. We have characterized a chimeric transcription unit (cat eye syndrome critical region gene 7, CECR7) formed from three duplicons in the pericentromeric region of chromosome 22q. CECR7 exons show similarity to sequences on chromosomes 2, 5, 7, 10, 11, 12, 13, 14, 15, 16, 18, 19, 21, and elsewhere on 22. Based on polymerase chain reaction (PCR) analysis of CECR7 duplicon boundaries in various primate species, and the sequence divergence between the human duplicons and their putative ancestral human loci, CECR7 was probably formed before the separation of macaque and is therefore older than most previously reported pericentromeric duplicons. Expression of CECR7 was detected by RT-PCR in humans and gorilla fibroblasts, but not orangutan, suggesting that expression did not result immediately from the formation of this novel transcription unit, or that expression was silenced in orangutan following its formation.
Starting Page	57
Ending Page	61
Page Count	5
File Format	PDF
ISSN	03406717
Journal	Human Genetics
Volume Number	112
Issue Number	1
e-ISSN	14321203
Language	English
Publisher	Springer-Verlag
Publisher Date	2002-10-29
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Three duplicons form a novel chimeric transcription unit in the pericentromeric region of chromosome 22q11

Localization of the gene for Wieacker-Wolff syndrome in the pericentromeric region of the X chromosome

A new locus for otosclerosis, OTSC8, maps to the pericentromeric region of chromosome 9

A Large Polymorphic Repeat in the Pericentromeric Region of Human Chromosome 15q Contains Three Partial Gene Duplications

A study of cryptic terminal chromosome rearrangements in recurrent miscarriage couples detects unsuspected acrocentric pericentromeric abnormalities

Comparative map between chicken Chromosome 15 and human chromosomal region 12q24 and 22q11-q12

Structural analysis and physical mapping of a pericentromeric region of chromosome 5 of Arabidopsis thaliana

A human gene similar to Drosophila melanogaster peanut maps to the DiGeorge syndrome region of 22q11

Interchromosomal core duplicons drive both evolutionary instability and disease susceptibility of the Chromosome 8p23.1 region.

Three duplicons form a novel chimeric transcription unit in the pericentromeric region of chromosome 22q11

Similar Documents

Three duplicons form a novel chimeric transcription unit in the pericentromeric region of chromosome 22q11

Localization of the gene for Wieacker-Wolff syndrome in the pericentromeric region of the X chromosome

A new locus for otosclerosis, OTSC8, maps to the pericentromeric region of chromosome 9

A Large Polymorphic Repeat in the Pericentromeric Region of Human Chromosome 15q Contains Three Partial Gene Duplications

A study of cryptic terminal chromosome rearrangements in recurrent miscarriage couples detects unsuspected acrocentric pericentromeric abnormalities

Comparative map between chicken Chromosome 15 and human chromosomal region 12q24 and 22q11-q12

Structural analysis and physical mapping of a pericentromeric region of chromosome 5 of Arabidopsis thaliana

A human gene similar to Drosophila melanogaster peanut maps to the DiGeorge syndrome region of 22q11

Interchromosomal core duplicons drive both evolutionary instability and disease susceptibility of the Chromosome 8p23.1 region.

Three duplicons form a novel chimeric transcription unit in the pericentromeric region of chromosome 22q11