NDLI: Histopathological changes of juvenile Schistosoma japonicum harbored in mice treated orally with mefloquine at a smaller single dose

Content Provider	Springer Nature Link
Author	Zhang, Chao Wei Xiao, Shu hua
Copyright Year	2011
Abstract	The histopathological changes of 14-day-old Schistosoma japonicum induced by a smaller single dose of mefloquine have been studied. Twenty-three mice infected with 60–80 S. japonicum cercariae for 14 days were treated orally with mefloquine at a single dose of 200 mg/kg (free base), and groups of three mice were killed at various intervals posttreatment. The liver of each mouse was removed, fixed and processed routinely, and examined by light microscopy. Eight hours posttreatment, 38.2% and 39.8% of schistosomulum sections were classified as degenerated and dead, respectively. The degenerated schistosomula revealed in high dilatation of gut with disruption of gut mucosa, swelling of the worm body accompanied by looseness or extensive lysis of parenchymal tissues, and focal swelling or peeling of tegument, while dead worms showed that their damaged tegument adhered to the vessel and inflammatory cell attached on and penetrated into the worm body. Twenty-four hours to 3 days posttreatment, the degenerated schistosomulum sections decreased from 28.1% to 8.2%, while the sections of dead schistosomula increased from 60.0% to 74.8%. At these time periods, the damage intensity of degenerated schistosomula aggravated, while dead schistosomula showed disintegration of internal structures infiltrated by eosinophil-predominant inflammatory cells to form the dead worm abscess. Seven days to 14 days posttreatment, no normal schistosomulum section was observed, and the percentages of degenerated and dead worms further decreased from 3.4% to 3.0% and 34.4% to 12.6%, respectively. Meanwhile, 62.2% to 84.4% of dead worms developed to dead worm granulomas and part of them situated in early stage. Twenty-eight days posttreatment, only dead worm granulomas were observed in the liver sections and part of them developed to late stage. The results indicate that a smaller single mefloquine dose 200 mg/kg exhibits a potential and fast killing effect against S. japonicum juvenile and induces severe histopathological lesions.
Starting Page	2281
Ending Page	2288
Page Count	8
File Format	PDF
ISSN	09320113
Journal	Parasitology Research
Volume Number	110
Issue Number	6
e-ISSN	14321955
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-12-22
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Medical Microbiology Immunology Microbiology
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Veterinary Parasitology Insect Science

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Histopathological changes in adult Schistosoma japonicum harbored in mice treated with a single dose of mefloquine

Further observation on histopathological alterations of adult Schistosoma japonicum harbored in mice following treatment with mefloquine at a smaller single dose

Histopathological alteration of juvenile Schistosoma japonicum in mice following treatment with single-dose mefloquine

Ultrastructural alterations of juvenile Schistosoma japonicum harbored in mice following mefloquine administration

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