NDLI: In vivo albendazole treatment of Taenia crassiceps cysticerci strain WFU: proliferation, damage, and recovery

Content Provider	Springer Nature Link
Author	Zurabian, R. Aguilar Vega, L. Terrones Vargas, E. Cervera Hernández, M. E. Willms, K. Ruíz Velasco Acosta, S.
Copyright Year	2013
Abstract	Taenia crassiceps has been widely experimented as a model for in vitro and in vivo studies on drug responses. The purpose of this study was to treat BALB/c mice infected with T. crassiceps strain WFU with commercially available albendazole and to analyze the reduction in parasite infrapopulations. Here, we describe the reduction and apparent damage of T. crassicceps WFU cysticerci in infected mice after antihelminthic drug treatment and subsequent inoculation of those treated parasites into a naïve host. We were able to reduce significantly the parasite counts to 33 and 48 % after albendazole treatment for 20 or 25 days and compared with the untreated mice. We also observed morphological damage such as the partial blebbing in the tegument and parenchyma of treated parasites, as well as disorganized musculature and the loss of cell membranes in subtegumental tissue section. However, larvae from albendazole-treated mice inoculated into the next host were able to become re-established in the next murine host due, probably, to the survival of proliferative parasite cells.
Starting Page	3961
Ending Page	3968
Page Count	8
File Format	PDF
ISSN	09320113
Journal	Parasitology Research
Volume Number	112
Issue Number	11
e-ISSN	14321955
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2013-09-05
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Medical Microbiology Microbiology Immunology
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Veterinary Parasitology Insect Science

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