NDLI: Extracellular calcium deficiency and ryanodine inhibit Eimeria tenella sporozoite invasion in vitro

Content Provider	Springer Nature Link
Author	Schubert, Ulrike Fuchs, Jörg Zimmermann, Jana Jahn, Doreen Zoufal, Karen
Copyright Year	2005
Abstract	An in vitro assay system with Eimeria tenella sporozoites was used to study the effects of extracellular calcium and active agents affecting the invasion of parasites into host cells. At concentrations of 900μM Ca2+ and less the invasion rates were distinctly decreased. Ryanodine, a herbal alkaloid known for binding to internal Ca2+ channels (ryanodine receptors), showed an inhibitory effect on E. tenella sporozoite invasion. Preincubation tests and staining with a fluorescent derivative of ryanodine assured that the compound bound specifically to the sporozoites and affected them rather than the host cells.
Starting Page	59
Ending Page	62
Page Count	4
File Format	PDF
ISSN	09320113
Journal	Parasitology Research
Volume Number	97
Issue Number	1
e-ISSN	14321955
Language	English
Publisher	Springer-Verlag
Publisher Date	2005-06-11
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Apicomplexa Calcium Eimeria tenella Invasion Ryanodine
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Veterinary Parasitology Insect Science

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Extracellular calcium deficiency and ryanodine inhibit Eimeria tenella sporozoite invasion in vitro