NDLI: A rationale to design longer lasting mosquito repellents

Content Provider	Springer Nature Link
Author	Iovinella, Immacolata Pelosi, Paolo Conti, Barbara
Copyright Year	2014
Abstract	Mosquito repellents represent a cleaner and safer alternative for population control and reduce the diseases they carry in large areas of the world. Recently, research has been focused on repellents of natural origins, both crude essential oils and their main constituents. We have observed that, although a large number of compounds can be efficiently used as mosquito repellents, their efficacy is never higher than those of commercial products DEET and Icaridin. Reasoning that probably specific and exceptionally active repellents might not exist, we focused our research on products that could provide longer protection times with respect to current commercial formulations while being used at lower concentrations. Based on the structure of menthone, a moderate natural repellent, we designed and synthesised some cyclic ketals that, because of their reduced volatility, could be effective for longer periods. In particular, a 1 % solution of one of such derivatives can still reduce mosquito bites by 90 % after 2 h, while DEET provides the same performance only for 15 min, when used at the same concentration. The approach we illustrate can be applied to other compounds and other systems and offers the additional advantage that derivatives of reduced volatility are also endowed with weaker odours.
Starting Page	1813
Ending Page	1820
Page Count	8
File Format	PDF
ISSN	09320113
Journal	Parasitology Research
Volume Number	113
Issue Number	5
e-ISSN	14321955
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-03-06
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Mosquito repellent Aedes albopictus Protection time Menthone Human-bait test DEET Medical Microbiology Microbiology Immunology
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Veterinary Parasitology Insect Science

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