NDLI: Positive correlation between Merkel cell polyomavirus viral load and capsid-specific antibody titer

Please wait, while we are loading the content...

The protective Th1 response in mice is induced in the T-cell zone only three weeks after infection with Leishmania major and not during early T-cell activation

MTOR signaling pathway regulates the IL-12/IL-10 axis in Leishmania donovani infection

A crucial role for IL-6 in the CNS of rats during fever induced by the injection of live E. coli

Neuraminidase inhibitor susceptibility of swine influenza A viruses isolated in Germany between 1981 and 2008

Neurocysticercosis: local and systemic immune-inflammatory features related to severity

Rot and Agr system modulate fibrinogen-binding ability mainly by regulating clfB expression in Staphylococcus aureus NCTC8325

Activation of MAPK/c-Fos induced responses in oral epithelial cells is specific to Candida albicans and Candida dubliniensis hyphae

Probing of the nuclear import and export signals and subcellular transport mechanism of varicella-zoster virus tegument protein open reading frame 10

High detection rate of Trichomonas vaginalis in benign hyperplastic prostatic tissue

Medical Microbiology and Immunology : Volume 200

Medical Microbiology and Immunology : Volume 199

Medical Microbiology and Immunology : Volume 198

Medical Microbiology and Immunology : Volume 197

Medical Microbiology and Immunology : Volume 196

Medical Microbiology and Immunology : Volume 195

Medical Microbiology and Immunology : Volume 194

Medical Microbiology and Immunology : Volume 193

Medical Microbiology and Immunology : Volume 192

Medical Microbiology and Immunology : Volume 191

Medical Microbiology and Immunology : Volume 190

Medical Microbiology and Immunology : Volume 189

Medical Microbiology and Immunology : Volume 188

Medical Microbiology and Immunology : Volume 187

Medical Microbiology and Immunology : Volume 186

Medical Microbiology and Immunology : Volume 185

Positive correlation between Merkel cell polyomavirus viral load and capsid-specific antibody titer

Content Provider	Springer Nature Link
Author	Pastrana, Diana V. Wieland, Ulrike Silling, Steffi Buck, Christopher B. Pfister, Herbert
Copyright Year	2011
Abstract	Merkel cell polyomavirus (MCPyV or MCV) is the first polyomavirus to be clearly implicated as a causal agent underlying a human cancer, Merkel cell carcinoma (MCC). Infection with MCPyV is common in the general population, and a majority of adults shed MCPyV from the surface of their skin. In this study, we quantitated MCPyV DNA in skin swab specimens from healthy volunteers sampled at different anatomical sites over time periods ranging from 3 months to 4 years. The volunteers were also tested using a serological assay that detects antibodies specific for the MCPyV virion. There was a positive correlation between MCPyV virion-specific antibody titers and viral load at all anatomical sites tested (dorsal portion of the hands, forehead, and buttocks) (Spearman’s r 0.644, P < 0.0001). The study results are consistent with previous findings suggesting that the skin is primary site of chronic MCPyV infection in healthy adults and suggest that the magnitude of an individual’s seroresponsiveness against the MCPyV virion generally reflects the overall MCPyV DNA load across wide areas of the skin. In light of previous reports indicating a correlation between MCC and strong MCPyV-specific seroresponsiveness, this model suggests that poorly controlled chronic MCPyV infection might be a risk factor in the development of MCC.
Starting Page	17
Ending Page	23
Page Count	7
File Format	PDF
ISSN	03008584
Journal	Medical Microbiology and Immunology
Volume Number	201
Issue Number	1
e-ISSN	14321831
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-05-26
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	MCV MCPyV Merkel cell polyomavirus Neutralization Viral load Skin Immunology Medical Microbiology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology Microbiology (medical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

ORIGINAL INVESTIGATION Positive correlation between Merkel cell polyomavirus viral load and capsid-specific antibody titer (2011)

Positive correlation between Merkel cell polyomavirus viral load and capsid-specific antibody titer

Quantitation of Human Seroresponsiveness to Merkel

Microenvironment and Immunology Antibodies to Merkel Cell Polyomavirus T Antigen Oncoproteins Reflect Tumor Burden in Merkel Cell Carcinoma Patients

Microenvironment and Immunology Antibodies to Merkel Cell Polyomavirus T Antigen Oncoproteins Reflect Tumor Burden in Merkel Cell Carcinoma Patients

Decreased IgG Antibody Response to Viral Protein Mimotopes of Oncogenic Merkel Cell Polyomavirus in Sera From Healthy Elderly Subjects

Merkel cell polyomavirus (MCPyV) strains in Japanese merkel cell carcinomas (MCC) are distinct from Caucasian type MCPyVs: genetic variability and phylogeny of MCPyV genomes obtained from Japanese MCPyV-infected MCCs

Merkel cell polyomavirus in cutaneous swabs.

Distinct merkel cell polyomavirus molecular features in tumour and non tumour specimens from patients with merkel cell carcinoma (2010)

Positive correlation between Merkel cell polyomavirus viral load and capsid-specific antibody titer

Similar Documents

ORIGINAL INVESTIGATION Positive correlation between Merkel cell polyomavirus viral load and capsid-specific antibody titer (2011)

Positive correlation between Merkel cell polyomavirus viral load and capsid-specific antibody titer

Quantitation of Human Seroresponsiveness to Merkel

Microenvironment and Immunology Antibodies to Merkel Cell Polyomavirus T Antigen Oncoproteins Reflect Tumor Burden in Merkel Cell Carcinoma Patients

Microenvironment and Immunology Antibodies to Merkel Cell Polyomavirus T Antigen Oncoproteins Reflect Tumor Burden in Merkel Cell Carcinoma Patients

Decreased IgG Antibody Response to Viral Protein Mimotopes of Oncogenic Merkel Cell Polyomavirus in Sera From Healthy Elderly Subjects

Merkel cell polyomavirus (MCPyV) strains in Japanese merkel cell carcinomas (MCC) are distinct from Caucasian type MCPyVs: genetic variability and phylogeny of MCPyV genomes obtained from Japanese MCPyV-infected MCCs

Merkel cell polyomavirus in cutaneous swabs.

Distinct merkel cell polyomavirus molecular features in tumour and non tumour specimens from patients with merkel cell carcinoma (2010)

Positive correlation between Merkel cell polyomavirus viral load and capsid-specific antibody titer