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| Content Provider | Springer Nature Link |
|---|---|
| Author | Cai, Mingsheng Wang, Shuai Long, Jing Zheng, Chunfu |
| Copyright Year | 2011 |
| Abstract | Varicella-zoster virus open reading frame 10 (ORF10), a tegument protein present in the virion, is a member of the alphaherpesvirus UL48 gene family that shares considerable amino acid sequence homology with the UL48 prototype, herpes simplex virus type 1 VP16. VP16 serves multiple functions, including transcriptional activation of viral immediate-early genes. Furthermore, VP16 has been shown to be involved in some aspects of virus assembly and/or maturation. However, little is known concerning the function of ORF10. Here, we found that transient expression of ORF10 fused to enhanced yellow fluorescent protein (EYFP) in COS-7 cells showed the predominantly nuclear localization in the absence of other viral proteins. By constructing a series of ORF10 variants fused to EYFP, a bona fide bipartite nuclear localization signal of ORF10 was, for the first time, determined and mapped to amino acids (aa) 302–347. Additionally, the nuclear export signal (NES) was identified and found to be in a leucine-rich region at aa 226–236. Finally, ORF10 was demonstrated to be targeted to the cytoplasm through the functional NES by chromosomal region maintenance 1-dependent pathway, and to the nucleus via Ran and importin β1-dependent pathway that does not require importin α5. |
| Starting Page | 103 |
| Ending Page | 111 |
| Page Count | 9 |
| File Format | |
| ISSN | 03008584 |
| Journal | Medical Microbiology and Immunology |
| Volume Number | 201 |
| Issue Number | 1 |
| e-ISSN | 14321831 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2011-07-14 |
| Publisher Place | Berlin/Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Open reading frame 10 (ORF10) Nuclear localization signal (NLS) Nuclear export signal (NES) Ran-GTP Chromosomal region maintenance 1 (CRM1) Importin Immunology Medical Microbiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology Microbiology (medical) |
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