NDLI: Paralemniscal TIP39 is induced in rat dams and may participate in maternal functions

Content Provider	Springer Nature Link
Author	Varga, Tamás Mogyoródi, Bence Bagó, Attila G. Cservenák, Melinda Domokos, Dominika Renner, Éva Gallatz, Katalin Usdin, Ted B. Palkovits, Miklós Dobolyi, Arpád
Copyright Year	2011
Abstract	The paralemniscal area, situated between the pontine reticular formation and the lateral lemniscus in the pontomesencephalic tegmentum contains some tuberoinfundibular peptide of 39 residues (TIP39)-expressing neurons. In the present study, we measured a 4 times increase in the level of TIP39 mRNA in the paralemniscal area of lactating mothers as opposed to nulliparous females and mothers deprived of pups using real-time RT-PCR. In situ hybridization histochemistry and immunolabeling demonstrated that the induction of TIP39 in mothers takes place within the medial paralemniscal nucleus, a cytoarchitectonically distinct part of the paralemniscal area, and that the increase in TIP39 mRNA levels translates into elevated peptide levels in dams. The paralemniscal area has been implicated in maternal control as well as in pain perception. To establish the function of induced TIP39, we investigated the activation of TIP39 neurons in response to pup exposure as maternal, and formalin injection as noxious stimulus. Both stimuli elicited c-fos expression in the paralemniscal area. Subsequent double labeling demonstrated that 95% of neurons expressing Fos in response to pup exposure also contained TIP39 immunoreactivity and 91% of TIP39 neurons showed c-fos activation by pup exposure. In contrast, formalin-induced Fos does not co-localize with TIP39. Instead, most formalin-activated neurons are situated medial to the TIP39 cell group. Our data indicate that paralemniscal neurons may be involved in the processing of maternal and nociceptive information. However, two different groups of paralemniscal neurons participate in the two functions. In particular, TIP39 neurons may participate in the control of maternal functions.
Starting Page	323
Ending Page	335
Page Count	13
File Format	PDF
ISSN	18632653
Journal	Anatomy and Embryology
Volume Number	217
Issue Number	2
e-ISSN	18632661
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-11-12
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Tuberoinfundibular peptide of 39 residues Parathyroid hormone 2 receptor Medial paralemniscal nucleus Formalin pain stress A7 noradrenergic cell group Pontine tegmentum Suckling Cell Biology Neurology Neurosciences
Content Type	Text
Resource Type	Article
Subject	Neuroscience Anatomy Histology

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Paralemniscal TIP39 is induced in rat dams and may participate in maternal functions

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