NDLI: Neuroanatomical changes in a mouse model of early life neglect

Content Provider	Springer Nature Link
Author	Duque, Alvaro Coman, Daniel Carlyle, Becky C. Bordner, Kelly A. George, Elizabeth D. Papademetris, Xephon Hyder, Fahmeed Simen, Arthur A.
Copyright Year	2011
Abstract	Using a novel mouse model of early life neglect and abuse (ENA) based on maternal separation with early weaning, George et al. (BMC Neurosci 11:123, 2010) demonstrated behavioral abnormalities in adult mice, and Bordner et al. (Front Psychiatry 2(18):1–18, 2011) described concomitant changes in mRNA and protein expression. Using the same model, here we report neuroanatomical changes that include smaller brain size and abnormal inter-hemispheric asymmetry, decreases in cortical thickness, abnormalities in subcortical structures, and white matter disorganization and atrophy most severely affecting the left hemisphere. Because of the similarities between the neuroanatomical changes observed in our mouse model and those described in human survivors of ENA, this novel animal model is potentially useful for studies of human ENA too costly or cumbersome to be carried out in primates. Moreover, our current knowledge of the mouse genome makes this model particularly suited for targeted anatomical, molecular, and pharmacological experimentation not yet possible in other species.
Starting Page	459
Ending Page	472
Page Count	14
File Format	PDF
ISSN	18632653
Journal	Anatomy and Embryology
Volume Number	217
Issue Number	2
e-ISSN	18632661
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-10-08
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Mouse models Brain asymmetry Diffusion tensor imaging (DTI) Early life neglect and abuse (ENA) Maternal separation Cell Biology Neurology Neurosciences
Content Type	Text
Resource Type	Article
Subject	Neuroscience Anatomy Histology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Neuroanatomical changes in a mouse model of early life neglect

Mapping of the mouse olfactory system with manganese-enhanced magnetic resonance imaging and diffusion tensor imaging

More insights into early brain development through statistical analyses of eigen-structural elements of diffusion tensor imaging using multivariate adaptive regression splines

Diffusion tensor imaging reveals evolution of primate brain architectures

Maternal separation with early weaning: a novel mouse model of early life neglect

Disrupted brain anatomical connectivity in medication-naïve patients with first-episode schizophrenia

Relationships between hippocampal microstructure, metabolism, and function in early Alzheimer’s disease

Multi-parametric evaluation of the white matter maturation

Differences in integrity of white matter and changes with training in spelling impaired children: a diffusion tensor imaging study

Neuroanatomical changes in a mouse model of early life neglect

Similar Documents

Neuroanatomical changes in a mouse model of early life neglect

Mapping of the mouse olfactory system with manganese-enhanced magnetic resonance imaging and diffusion tensor imaging

More insights into early brain development through statistical analyses of eigen-structural elements of diffusion tensor imaging using multivariate adaptive regression splines

Diffusion tensor imaging reveals evolution of primate brain architectures

Maternal separation with early weaning: a novel mouse model of early life neglect

Disrupted brain anatomical connectivity in medication-naïve patients with first-episode schizophrenia

Relationships between hippocampal microstructure, metabolism, and function in early Alzheimer’s disease

Multi-parametric evaluation of the white matter maturation

Differences in integrity of white matter and changes with training in spelling impaired children: a diffusion tensor imaging study

Neuroanatomical changes in a mouse model of early life neglect