NDLI: Neuroligin-1 regulates excitatory synaptic transmission, LTP and EPSP-spike coupling in the dentate gyrus in vivo

Please wait, while we are loading the content...

Extracellular signal-regulated kinase1/2-dependent changes in tight junctions after ischemic preconditioning contributes to tolerance induction after ischemic stroke

Experimental focal neocortical epilepsy is associated with reduced white matter volume growth: results from multiparametric MRI analysis

Dynamic brain functional connectivity modulated by resting-state networks

Neuroligin-1 regulates excitatory synaptic transmission, LTP and EPSP-spike coupling in the dentate gyrus in vivo

Discordant cerebral lateralisation for verbal fluency is not an artefact of attention: evidence from MzHd twins

Schizophrenia-like phenotype of polysialyltransferase ST8SIA2-deficient mice

MRI anatomical variants of mammillary bodies

DISC1 Ser704Cys impacts thalamic-prefrontal connectivity

Multivariate classification of social anxiety disorder using whole brain functional connectivity

Distribution and neurochemical characterization of neurons in the rat ventrolateral medulla activated by glucoprivation

Exclusive neuronal expression of SUCLA2 in the human brain

Loss of hippocampal interneurons and epileptogenesis: a comparison of two animal models of acquired epilepsy

The multispecific thyroid hormone transporter OATP1C1 mediates cell-specific sulforhodamine 101-labeling of hippocampal astrocytes

Receptor architecture of visual areas in the face and word-form recognition region of the posterior fusiform gyrus

Action selection in a possible model of striatal medium spiny neuron dysfunction: behavioral and EEG data in a patient with benign hereditary chorea

Effects of postnatal hyperoxia exposure on the rat dentate gyrus and subventricular zone

Shifted neuronal balance during stimulus–response integration in schizophrenia: an fMRI study

Projections from the central amygdaloid nucleus to the precuneiform nucleus in the mouse

Bimanual motor deficits in older adults predicted by diffusion tensor imaging metrics of corpus callosum subregions

Optic radiation structure and anatomy in the normally developing brain determined using diffusion MRI and tractography

Changes in the integrity of thalamocortical connections are associated with sensorimotor deficits in children with congenital hemiplegia

Gray and white matter structures in the midcingulate cortex region contribute to body mass index in Chinese young adults

Anatomical and electrophysiological changes in striatal TH interneurons after loss of the nigrostriatal dopaminergic pathway

Retrograde transneuronal degeneration in the retina and lateral geniculate nucleus of the V1-lesioned marmoset monkey

In contrast to many other mammals, cetaceans have relatively small hippocampi that appear to lack adult neurogenesis

Comparative analysis of the serotonergic systems in the CNS of two lungfishes, Protopterus dolloi and Neoceratodus forsteri

Not on speaking terms: hallucinations and structural network disconnectivity in schizophrenia

MeCP2-mediated alterations of striatal features accompany psychomotor deficits in a mouse model of Rett syndrome

Deficits in memory and visuospatial learning correlate with regional hippocampal atrophy in MS

Investigating the ventral-lexical, dorsal-sublexical model of basic reading processes using diffusion tensor imaging

Enhanced characterization of the zebrafish brain as revealed by super-resolution track-density imaging

Higher volume of ventral striatum and right prefrontal cortex in pathological gambling

An animal model mimicking pedunculopontine nucleus cholinergic degeneration in Parkinson’s disease

Functional changes during working memory in Huntington’s disease: 30-month longitudinal data from the IMAGE-HD study

Altered striatal and pallidal connectivity in cervical dystonia

Genetic absence of the vesicular inhibitory amino acid transporter differentially regulates respiratory and locomotor motor neuron development

Direct targeting of peptidergic amygdalar neurons by noradrenergic afferents: linking stress-integrative circuitry

Hippocampal 5-HT1A receptor binding is related to object–location memory in humans

Erratum to: Onset-related differences in neural substrates of tinnitus-related distress: the anterior cingulate cortex in late-onset tinnitus, and the frontal cortex in early-onset tinnitus

Anatomy and Embryology : Volume 219

Anatomy and Embryology : Volume 218

Anatomy and Embryology : Volume 217

Anatomy and Embryology : Volume 216

Anatomy and Embryology : Volume 215

Anatomy and Embryology : Volume 214

Anatomy and Embryology : Volume 213

Anatomy and Embryology : Volume 212

Anatomy and Embryology : Volume 211

Anatomy and Embryology : Volume 210

Anatomy and Embryology : Volume 209

Anatomy and Embryology : Volume 208

Anatomy and Embryology : Volume 207

Anatomy and Embryology : Volume 206

Anatomy and Embryology : Volume 205

Anatomy and Embryology : Volume 204

Anatomy and Embryology : Volume 203

Anatomy and Embryology : Volume 202

Anatomy and Embryology : Volume 201

Anatomy and Embryology : Volume 200

Anatomy and Embryology : Volume 199

Anatomy and Embryology : Volume 198

Anatomy and Embryology : Volume 197

Anatomy and Embryology : Volume 196

Anatomy and Embryology : Volume 195

Neuroligin-1 regulates excitatory synaptic transmission, LTP and EPSP-spike coupling in the dentate gyrus in vivo

Content Provider	Springer Nature Link
Author	Jedlicka, Peter Vnencak, Matej Krueger, Dilja D. Jungenitz, Tassilo Brose, Nils Schwarzacher, Stephan W.
Copyright Year	2013
Abstract	Neuroligins are transmembrane cell adhesion proteins with a key role in the regulation of excitatory and inhibitory synapses. Based on previous in vitro and ex vivo studies, neuroligin-1 (NL1) has been suggested to play a selective role in the function of glutamatergic synapses. However, the role of NL1 has not yet been investigated in the brain of live animals. We studied the effects of NL1-deficiency on synaptic transmission in the hippocampal dentate gyrus using field potential recordings evoked by perforant path stimulation in urethane-anesthetized NL1 knockout (KO) mice. We report that in NL1 KOs the activation of glutamatergic perforant path granule cell inputs resulted in reduced synaptic responses. In addition, NL1 KOs displayed impairment in long-term potentiation. Furthermore, field EPSP-population spike (E-S) coupling was greater in NL1 KO than WT mice and paired-pulse inhibition was reduced, indicating a compensatory rise of excitability in NL1 KO granule cells. Consistent with changes in excitatory transmission, NL1 KOs showed a significant reduction in hippocampal synaptosomal expression levels of the AMPA receptor subunit GluA2 and NMDA receptor subunits GluN1, GluN2A and GluN2B. Taken together, we provide first evidence that NL1 is essential for normal excitatory transmission and long-term synaptic plasticity in the hippocampus of intact animals. Our data provide insights into synaptic and circuit mechanisms of neuropsychiatric abnormalities such as learning deficits and autism.
Starting Page	47
Ending Page	58
Page Count	12
File Format	PDF
ISSN	18632653
Journal	Anatomy and Embryology
Volume Number	220
Issue Number	1
e-ISSN	18632661
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2013-09-29
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Dentate granule cells Perforant path Excitability Synaptic plasticity Paired-pulse inhibition Cell adhesion molecule Neurosciences Cell Biology Neurology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Anatomy Histology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The amyloid precursor protein regulates synaptic transmission at medial perforant path synapses (Dataset)

GABA synapses and the rapid loss of inhibition to dentate gyrus granule cells after brief perforant-path stimulation

Burst firing is required for induction of Hebbian LTP at lateral perforant path to hippocampal granule cell synapses

Attenuated bidirectional short-term synaptic plasticity in the dentate gyrus of Schnurri-2 knockout mice, a model of schizophrenia

Synaptic Plasticity and Excitation-Inhibition Balance in the Dentate Gyrus: Insights from In Vivo Recordings in Neuroligin-1, Neuroligin-2, and Collybistin Knockouts

Structural plasticity of the axon initial segment in rat hippocampal granule cells following high frequency stimulation and LTP induction

Deletion of the amyloid precursor-like protein 1 (APLP1) enhances excitatory synaptic transmission, reduces network inhibition but does not impair synaptic plasticity in the mouse dentate gyrus.

Studies of the Synaptic Plasticity of Field CA3 of the Hippocampus During Tetanization of the Perforant Path

Phosphorylation of ribosomal protein S6 as a mechanism to regulate translation at activated synapses

Neuroligin-1 regulates excitatory synaptic transmission, LTP and EPSP-spike coupling in the dentate gyrus in vivo

Similar Documents

The amyloid precursor protein regulates synaptic transmission at medial perforant path synapses (Dataset)

GABA synapses and the rapid loss of inhibition to dentate gyrus granule cells after brief perforant-path stimulation

Burst firing is required for induction of Hebbian LTP at lateral perforant path to hippocampal granule cell synapses

Attenuated bidirectional short-term synaptic plasticity in the dentate gyrus of Schnurri-2 knockout mice, a model of schizophrenia

Synaptic Plasticity and Excitation-Inhibition Balance in the Dentate Gyrus: Insights from In Vivo Recordings in Neuroligin-1, Neuroligin-2, and Collybistin Knockouts

Structural plasticity of the axon initial segment in rat hippocampal granule cells following high frequency stimulation and LTP induction

Deletion of the amyloid precursor-like protein 1 (APLP1) enhances excitatory synaptic transmission, reduces network inhibition but does not impair synaptic plasticity in the mouse dentate gyrus.

Studies of the Synaptic Plasticity of Field CA3 of the Hippocampus During Tetanization of the Perforant Path

Phosphorylation of ribosomal protein S6 as a mechanism to regulate translation at activated synapses

Neuroligin-1 regulates excitatory synaptic transmission, LTP and EPSP-spike coupling in the dentate gyrus in vivo