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Abnormal processing of deontological guilt in obsessive–compulsive disorder

Content Provider	Springer Nature Link
Author	Basile, Barbara Mancini, Francesco Macaluso, Emilia Caltagirone, Carlo Bozzali, Marco
Copyright Year	2013
Abstract	Guilt plays a significant role in the occurrence and maintenance of obsessive–compulsive disorder (OCD). Two major types of guilt have been identified: one deriving from the transgression of a moral rule (deontological guilt DG), another (altruistic guilt AG), relying on the assumption of having compromised a personal altruistic goal. Clinical evidence suggests that OCD patients are particularly sensitive to DG, but not AG. In this functional magnetic resonance imaging (fMRI) study, we investigated brain response of OCD patients while processing DG and AG stimuli. A previously validated fMRI paradigm was used to selectively evoke DG and AG, and anger and sadness, as control emotions in 13 OCD patients and 19 healthy controls. Patients’ behavioral results showed a prominent attitude to experience guilt, compared to controls, while accomplishing task. fMRI results revealed that patients have reduced activation in the anterior cingulate (ACC) and frontal gyrus when experiencing guilt, regardless of its specific type (DG or AG). When separately considering each type of guilt (against each of its control), patients showed decreased activation in the ACC, the insula and the precuneus, for DG. No significant differences were observed between groups when processing AG, anger or sad stimuli. This study provides evidence for an abnormal processing of guilt, and specifically DG, in OCD patients. We suggest that decreased activation may reflect patients’ cerebral efficiency, which derives from their frequent exposure to guilty feelings (“neural efficiency hypothesis”). In conclusion, our study confirms a selective abnormal processing of guilt, and specifically DG, in OCD.
Starting Page	1321
Ending Page	1331
Page Count	11
File Format	PDF
ISSN	18632653
Journal	Anatomy and Embryology
Volume Number	219
Issue Number	4
e-ISSN	18632661
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2013-05-17
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Obsessive–compulsive disorder Neuroimaging Guilt Deontological guilt Altruistic guilt Emotional processing Neurosciences Cell Biology Neurology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Anatomy Histology

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