NDLI: Developmental expression of COE across the Metazoa supports a conserved role in neuronal cell-type specification and mesodermal development

Content Provider	Springer Nature Link
Author	Jackson, Daniel J. Meyer, Néva P. Seaver, Elaine Pang, Kevin McDougall, Carmel Moy, Vanessa N. Gordon, Kacy Degnan, Bernard M. Martindale, Mark Q. Burke, Robert D. Peterson, Kevin J.
Copyright Year	2010
Abstract	The transcription factor COE (collier/olfactory-1/early B cell factor) is an unusual basic helix–loop–helix transcription factor as it lacks a basic domain and is maintained as a single copy gene in the genomes of all currently analysed non-vertebrate Metazoan genomes. Given the unique features of the COE gene, its proposed ancestral role in the specification of chemosensory neurons and the wealth of functional data from vertebrates and Drosophila, the evolutionary history of the COE gene can be readily investigated. We have examined the ways in which COE expression has diversified among the Metazoa by analysing its expression from representatives of four disparate invertebrate phyla: Ctenophora (Mnemiopsis leidyi); Mollusca (Haliotis asinina); Annelida (Capitella teleta and Chaetopterus) and Echinodermata (Strongylocentrotus purpuratus). In addition, we have studied COE function with knockdown experiments in S. purpuratus, which indicate that COE is likely to be involved in repressing serotonergic cell fate in the apical ganglion of dipleurula larvae. These analyses suggest that COE has played an important role in the evolution of ectodermally derived tissues (likely primarily nervous tissues) and mesodermally derived tissues. Our results provide a broad evolutionary foundation from which further studies aimed at the functional characterisation and evolution of COE can be investigated.
Starting Page	221
Ending Page	234
Page Count	14
File Format	PDF
ISSN	0949944X
Journal	Development Genes and Evolution
Volume Number	220
Issue Number	7-8
e-ISSN	1432041X
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-11-11
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	COE Ectoderm Mesoderm Neurogenesis Metazoa Animal Genetics and Genomics Neurosciences Biochemistry Cell Biology Developmental Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Developmental Biology

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