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| Content Provider | Springer Nature Link |
|---|---|
| Author | Wexler, Judith R. Plachetzki, David C. Kopp, Artyom |
| Copyright Year | 2014 |
| Abstract | The family of Doublesex-Mab-3 Related Transcription factors (DMRTs) includes key regulators of sexual differentiation and neurogenesis. To help understand the functional diversification of this gene family, we examined DMRT gene complements from the whole genome sequences and predicted gene models of 32 animal species representing 12 different phyla and from several non-metazoan outgroups. DMRTs are present in all animals except the sponge Amphimedon queenslandica, but are not found in any of the outgroups, indicating that this gene family is specific to animals and has an ancient pre-eumetazoan origin. Our analyses suggest that DMRT genes diversified independently in bilaterian and non-bilaterian animals. Most clades in the DMRT gene tree, including those containing the well-characterized DMRT1 and doublesex genes, have phylogenetically limited distributions. |
| Starting Page | 175 |
| Ending Page | 181 |
| Page Count | 7 |
| File Format | |
| ISSN | 0949944X |
| Journal | Development Genes and Evolution |
| Volume Number | 224 |
| Issue Number | 3 |
| e-ISSN | 1432041X |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2014-06-06 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Doublesex-mab-3 related transcription factor Gene tree Phylogenetics Sex determination Evolution Developmental Biology Neurosciences Cell Biology Biochemistry Animal Genetics and Genomics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Developmental Biology |
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