NDLI: Delayed contractures induced by external cadmium ions in rat soleus muscle fibres

Content Provider	Springer Nature Link
Author	Mould, J. Dulhunty, A. F.
Copyright Year	2000
Abstract	Cd2+-induced contractures began with a delay of ≅4 min after adding 3 mM Cd2+ to external solutions that contained Cl– as the major anion. Tension increased to ≅20% of peak tetanic tension after 30 min and was maintained after Cd2+ washout. Tension developed more rapidly at higher [Cd2+] (up to 10 mM). There was a lack of correlation between the delay before the contracture and contracture tension: (1) tension was reduced by 2 mM Co2+ or 50 µM nifedipine, although the delay remained at ≅4 min, and (2) the delay fell to seconds when Cd2+ was added in SO4 2– solutions, although tension was the same as in Cl– solutions. Since SO4 2– solutions swell T-tubules, Cd2+ may enter the T-system before inducing contractures. Cd2+-induced contractures depended on external [Ca2+] since they were reduced when Ca2+ was omitted from solutions. The contractures did not depend on activation of excitation–contraction coupling, since tension was not altered when the voltage sensor was inactivated by depolarization in 40 mM K+. A small contracture developed with 3 mM Zn2+, but not 3 mM Co2+ or La3+. Both Cd2+ and Zn2+ activated the contractile proteins in skinned fibres. Cd2+-induced contractures may depend on external Cd2+ releasing Ca2+ from the sarcoplasmic reticulum (SR), or on Cd2+ entering the fibre, releasing Ca2+ from the SR and/or directly activating the contractile proteins.
Starting Page	263
Ending Page	270
Page Count	8
File Format	PDF
ISSN	00316768
Journal	Pflügers Archiv
Volume Number	439
Issue Number	3
e-ISSN	14322013
Language	English
Publisher	Springer-Verlag
Publisher Date	1999-10-30
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Human Physiology
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Clinical Biochemistry

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