NDLI: Changes in contractile properties of skinned single rat soleus and diaphragm fibres after chronic hypoxia

Content Provider	Springer Nature Link
Author	Degens, Hans Bosutti, Alessandra Gilliver, Sally F. Slevin, Mark Heijst, Ar Wüst, Rob C. I.
Copyright Year	2010
Abstract	Hypoxia may be one of the factors underlying muscle dysfunction during ageing and chronic lung and heart failure. Here we tested the hypothesis that chronic hypoxia per se affects contractile properties of single fibres of the soleus and diaphragm muscle. To do this, the force–velocity relationship, rate of force redevelopment and calcium sensitivity of single skinned fibres from normoxic rats and rats exposed to 4 weeks of hypobaric hypoxia (410 mmHg) were investigated. The reduction in maximal force (P 0) after hypoxia (p = 0.031) was more pronounced in type IIa than type I fibres and was mainly attributable to a reduction in fibre cross-sectional area (p = 0.044). In type IIa fibres this was aggravated by a reduction in specific tension (p = 0.001). The maximal velocity of shortening (V max) and shape of the force velocity relation (a/P 0), however, did not differ between normoxic and hypoxic muscle fibres and the reduction in maximal power of hypoxic fibres (p = 0.012) was mainly due to a reduction in P 0. In conclusion, chronic hypoxia causes muscle fibre dysfunction which is not only due to a loss of muscle mass, but also to a diminished force generating capacity of the remaining contractile material. These effects are similar in the soleus and diaphragm muscle, but more pronounced in type IIa than I fibres.
Starting Page	863
Ending Page	873
Page Count	11
File Format	PDF
ISSN	00316768
Journal	Pflügers Archiv
Volume Number	460
Issue Number	5
e-ISSN	14322013
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-08-10
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Specific tension force–velocity Skeletal muscle power Human Physiology
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Clinical Biochemistry

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