NDLI: Interaction of syntaxin with a single Kv1.1 channel: a possible mechanism for modulating neuronal excitability

Content Provider	Springer Nature Link
Author	Michaelevski, Izhak Korngreen, Alon Lotan, Ilana
Copyright Year	2007
Abstract	Voltage-gated K+ channels are crucial for intrinsic neuronal plasticity and present a target for modulations by protein–protein interactions, notably, by exocytotic proteins demonstrated by us in several systems. Here, we investigated the interaction of a single Kv1.1 channel with syntaxin 1A. Syntaxin decreased the unitary conductance of all conductance states (two subconductances and a full conductance) and decreased their open probabilities by prolongation of mean closed dwell-times at depolarized potentials. However, at subthreshold potentials syntaxin 1A increased the probabilities of the subconductance states. Consequently, the macroscopic conductance is decreased at potentials above threshold and increased at threshold potentials. Numerical modeling based on steady-state and kinetic analyses suggests: (1) a mechanism whereby syntaxin controls activation gating by forcing the conductance pathway only via a sequence of discrete steps through the subconductance states, possibly via a breakdown of cooperative movements of voltage sensors that exist in Kv1.1; (2) a physiological effect, apparently paradoxical for an agent that reduces K+ current, of attenuating neuronal firing frequency via an increase in K+ shunting conductance. Such modulation of the gain of neuronal output in response to different levels of syntaxin is in accord with the suggested role for Kv1.1 in axonal excitability and synaptic efficacy.
Starting Page	477
Ending Page	494
Page Count	18
File Format	PDF
ISSN	00316768
Journal	Pflügers Archiv
Volume Number	454
Issue Number	3
e-ISSN	14322013
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-03-31
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Kv1.1 Single channel Subconductance levels Syntaxin 1A Shunting inhibition Human Physiology
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Clinical Biochemistry

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