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| Content Provider | Springer Nature Link |
|---|---|
| Author | Geraldes, Pedro Gosselin, Hugues Tanguay, Jean François Clément, Robert Calderone, Angeli |
| Copyright Year | 2007 |
| Abstract | Hormonal replacement therapy in postmenopausal women was associated with an increased incidence of nonfatal myocardial infarction. Selective estrogen receptor modulators were considered an alternative pharmacological approach. However, selective estrogen receptor modulators acting via estrogen receptor-dependent and receptor-independent mechanisms may negatively influence cardiac remodeling. The present study tested the hypothesis that tamoxifen (TAM) treatment after coronary artery ligation compromised scar formation. TAM administration (10 mg kg−1 day−1 for 3 weeks) to postmyocardial infarcted (MI) female adult rats significantly increased scar surface area (TAM+MI = 0.67 ± 0.08 vs MI = 0.45 ± 0.06 cm2) and weight (TAM+MI = 0.071 ± 0.007 vs MI = 0.050 ± 0.006 grams). In the infarct region, a significant decrease (p < 0.05) of small calibre vessels (lumen diameter <50 μm) was observed in TAM treated post-MI rats (4.5 ± 0.8 vessels/mm2), as compared to untreated MI rats (7 ± 0.7 vessels/mm2). Consistent with the latter finding, 4-OH TAM caused a dose-dependent suppression of vascular endothelial growth factor (VEGF)-stimulated (10−9 mol/l) capillarity-like tubule formation by rat aortic endothelial cells in vitro via an estrogen receptor-independent mechanism. These data have demonstrated that TAM treatment of post-MI female rats exacerbated scar formation and may have occurred at least in part via the attenuation of new vessel formation in the infarct region. |
| Starting Page | 385 |
| Ending Page | 393 |
| Page Count | 9 |
| File Format | |
| ISSN | 00316768 |
| Journal | Pflügers Archiv |
| Volume Number | 454 |
| Issue Number | 3 |
| e-ISSN | 14322013 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2007-02-07 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Heart Ischemia Vessels Reparative fibrosis Human Physiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Physiology (medical) Clinical Biochemistry |
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