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| Content Provider | Springer Nature Link |
|---|---|
| Author | Midrio, M. Danieli Betto, Daniela Megighian, Aram Betto, Romeo |
| Copyright Year | 1997 |
| Abstract | The Ca2+ release activity of the sarcoplasmic reticulum (SR) in chemically skinned single slow-twitch fibres from control, 2-day and 7-day denervated rat soleus muscle was studied. Histochemical fibre type composition of the whole muscle, electrophysiological properties and the Ca2+ sensitivity of tension development by single muscle fibres were also studied. All the data were correlated with contractile properties of the in vitro muscle. In the 2-day denervated muscle the SR Ca2+ capacity and the rate of Ca2+ uptake decreased from the control values of 0.384 ± 0.030 μmol (mg fibre protein)–1 and 19.8 ± 1.9 nmol min–1 (mg fibre protein)–1, respectively, to 0.210 ± 0.016 μmol (mg fibre protein)–1 and 13.5 ± 0.9 nmol min–1 (mg fibre protein)–1; the calculated amount of Ca2+ released upon stimulation by caffeine decreased from the control value of 0.148 to 0.078 μmol (mg fibre protein)–1. In the 7-day denervated muscle, the SR Ca2+ capacity and the rate of Ca2+ uptake increased to 0.517 ± 0.06 μmol (mg fibre protein)–1 and 21.6 ± 2.3 nmol min–1 (mg fibre protein)–1, respectively; the calculated amount of Ca2+ released increased to 0.217 μmol (mg fibre protein)–1. Both contraction time and tension of the isometric twitch decreased in 2-day denervated and increased in 7-day denervated muscles. Electrophysiological and histochemical changes, as well as changes in the Ca2+ sensitivity of the muscle fibres did not show any apparent correlation with mechanical changes. It is therefore concluded that the SR plays a prominent role in the early changes of contraction time and tension following denervation. |
| Starting Page | 398 |
| Ending Page | 405 |
| Page Count | 8 |
| File Format | |
| ISSN | 00316768 |
| Journal | Pflügers Archiv |
| Volume Number | 434 |
| Issue Number | 4 |
| e-ISSN | 14322013 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 1997-07-07 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Physiology (medical) Clinical Biochemistry |
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