NDLI: Changes in baroreceptor vagal reflex performance in the developing rat

Content Provider	Springer Nature Link
Author	Kasparov, S. Paton, Julian F. R.
Copyright Year	1997
Abstract	Ontogenesis of both vagal control of heart rate and the baroreceptor vagal reflex were evaluated in rats at postnatal ages (P) of 5/6, 10, 15, 20, 25 and >42 days anaesthetised with urethane (1.5 g/kg). Between P5/6 and P25 heart rate rose from 372 ± 12 to 448 ± 20 beats per minute and mean arterial pressure increased from 33.9 ± 3.1 to 74.59 ± 3.25 mm Hg (mean ± SEM, n = 7 and 11 respectively). Cardiac vagal tone was absent at P10 but significant at P20 (P < 0.05) as revealed with atropine (0.5–1 mg/kg i.v.). Baroreceptor cardiac reflex sensitivity, tested with phenylephrine (10–50 μg/kg i.v.), was attenuated significantly in P10–20 rats compared with P5/6, P25 and mature animals. In P14–17 rats stimulation of neurones in either the solitary tract or ambiguual nuclei, by microinjection of L-glutamate (100–200 pmol), evoked an atropine-sensitive bradycardia indicating a functional integrity of central and peripheral efferent pathways mediating the baroreceptor reflex. Thus, the baroreceptor vagal reflex is functional in P5/6 rats but becomes attenuated between P10–P20, which is coincident with the maturational rise in arterial pressure.
Starting Page	438
Ending Page	444
Page Count	7
File Format	PDF
ISSN	00316768
Journal	Pflügers Archiv
Volume Number	434
Issue Number	4
e-ISSN	14322013
Language	English
Publisher	Springer-Verlag
Publisher Date	1997-07-07
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Clinical Biochemistry

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