NDLI: Acute temperature sensitivity in optic nerve axons explained by an electrogenic membrane potential

Content Provider	Springer Nature Link
Author	Coates, Tom A. Woolugh, Oscar Masters, Joseph M. Asadova, Gulsum Chandrakumar, Charmilie Baker, Mark D.
Copyright Year	2015
Abstract	Classical work in squid axon reports resting membrane potential is independent of temperature, but our findings suggest that this is not the case for axons in mammalian optic nerve. Refractory period duration changes over 10 times between 37 °C and room temperature, and afterpotential polarity is also acutely temperature sensitive, inconsistent with changes in temperature impacting nerve function only through altered rates of ion channel gating kinetics. Our evidence suggests that the membrane potential is enhanced by warming, an effect reduced by exposure to ouabain. The temperature dependence can be explained if axonal Na+/K+ ATPase continuously expels Na+ ions that enter axons largely electroneutrally, thereby adding a substantial electrogenic component to the membrane potential. Block of the Na+ transporter NKCC1 with bumetanide increases refractoriness, like depolarization, indicating that this is a probable route by which Na+ enters, raising the expectation that the rate of electroneutral Na+ influx increases with temperature and suggesting a temperature-dependent transmembrane Na+ cycle that contributes to membrane potential.
Starting Page	2337
Ending Page	2349
Page Count	13
File Format	PDF
ISSN	00316768
Journal	Pflügers Archiv
Volume Number	467
Issue Number	11
e-ISSN	14322013
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2015-02-28
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Optic nerve Membrane potential Recovery cycle Na+/K+-ATPase NKCC1 Ouabain Bumetanide Human Physiology
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Clinical Biochemistry

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Acute temperature sensitivity in optic nerve axons explained by an electrogenic membrane potential

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