NDLI: Age and microvascular responses to knee extensor exercise in women

Content Provider	Springer Nature Link
Author	Parker, Beth A. Smithmyer, Sandra L. Ridout, Samuel J. Ray, Chester A. Proctor, David N.
Copyright Year	2008
Abstract	This study examined the relation between femoral artery hyperemic responses to leg exercise and microvascular oxygen extraction in nine young [(mean ± S.E.M) Y: 25 ± 1 years] and 13 older (O: 67 ± 1 years) healthy women. Femoral artery blood flow (FBF; Doppler ultrasound), mean arterial pressure (MAP), and femoral vascular conductance (FVC; FBF/MAP) were assessed at rest and during 9 min of ∼17–18 W single knee extensor exercise. Near-infrared spectroscopy (NIRS) in the vastus lateralis was used to measure changes in deoxyhemoglobin (HHb) and oxyhemoglobin (O2Hb) to assess oxygen extraction (Δ HHb), microvascular blood volume (Δ HHb + O2Hb), and spatial heterogeneity of blood volume (relative dispersion, defined as the coefficient of variation of measurements from all NIR sensors). During exercise, FBF and FVC were lower (p < 0.05) in O compared to Y (Y: 1,430 ± 101 mL min−1 and 16.6 ± 1.2 mL min−1 per mmHg versus O: 1,127 ± 64 mL min−1 and 10.9 ± 0.6 mL min−1per mmHg). While oxygen extraction increased more rapidly in Y, there were no age differences (p > 0.10) beyond the fourth min of exercise. In addition, the relative increase in microvascular blood volume was not significantly different during exercise in Y versus O (age effect: p = 0.87), although Y demonstrated an increase in blood volume heterogeneity in both the active and inactive leg (p = 0.02 and <0.05, respectively) not observed in O (p = 0.71 and 0.28, respectively). NIRS-derived measurements of changes in deoxygenated hemoglobin do not support the hypothesis that older women compensate for the blunted leg hyperemic response to knee extensor exercise through an augmentation of quadriceps oxygen extraction; knee extensor work may be accomplished by other metabolic or microvascular adjustments to exercise in older women.
Starting Page	343
Ending Page	351
Page Count	9
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	103
Issue Number	3
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	2008-03-19
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Oxygen extraction Heterogeneity Blood flow Sports Medicine Occupational Medicine/Industrial Medicine Human Physiology
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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