NDLI: Breath-by-breath fluctuations of pulmonary gas exchange and ventilation in COPD patients

Content Provider	Springer Nature Link
Author	Puente Maestu, Luis Abad, Mª Godoy, Raul Pérez Parra, José Cubillo, José M. Whipp, Brian J.
Copyright Year	2002
Abstract	The purpose of the study was to characterise statistically the inherent fluctuations in breath-by-breath measurements of pulmonary gas exchange (oxygen uptake and carbon dioxide output, VO2 and VCO2, respectively) and pulmonary ventilation (VE) in patients with chronic obstructive pulmonary disease (COPD) and to compare them with those of healthy control subjects. Thirty subjects with COPD [mean (SD): 67 (6) years old; forced expiratory volume in 1 min, FEV1 1.25( 0.18) l; 42 (6)% predicted FEV1] and 12 healthy subjects [31 (3) years old; FEV1 3.62 (0.54) l; 99 (8)% predicted FEV1] performed exercise tests on a cycle ergometer at a constant work rate of moderate intensity. Steady-state exercise values for VO2, VCO2 and VE were 905 (96) ml·min–1, 847(90) ml·min–1 and 23 (3) l·min–1, respectively for the COPD patients and 1239(89) ml·min–1, 1191(84) ml·min–1 and 37(3) l·min–1, respectively, for the healthy controls. The breath-by-breath fluctuations were well characterised by a Gaussian density-probability function with breath-to-breath autocorrelations that were not significantly different from 0, up to four subsequent breaths. Its magnitude varied among variables, but was independent of the signal amplitude for the same subject and variable. With ratios of amplitude of fluctuation:signal of around 10%, typical of the patients studied, the resolution of time constants and amplitude were ≅9 s and ≅100 ml·min–1, respectively for VO2 or VCO2 with one repetition.
Starting Page	535
Ending Page	541
Page Count	7
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	87
Issue Number	6
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	2002-07-09
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Assessment of breath-by-breath alveolar gas exchange: an alternative view of the respiratory cycle

Pulmonary gas exchange during apnoea in exercising men

CO2 rebreathing model in COPD: blood-to-gas equilibration

A new interpolation-free procedure for breath-by-breath analysis of oxygen uptake in exercise transients

Bronchodilator effect on ventilatory, pulmonary gas exchange, and heart rate kinetics during high-intensity exercise in COPD

Algorithms, modelling and $$ \dot{V}{\text{O}}_{ 2} $$ kinetics

Effect of sampling strategy on measures of V̇O2peak obtained using commercial breath-by-breath systems

New acquisitions in the assessment of breath-by-breath alveolar gas transfer in humans

Skeletal muscle ergoreflex overactivity is not related to exercise ventilatory inefficiency in non-hypoxaemic patients with COPD

Breath-by-breath fluctuations of pulmonary gas exchange and ventilation in COPD patients

Similar Documents

Assessment of breath-by-breath alveolar gas exchange: an alternative view of the respiratory cycle

Pulmonary gas exchange during apnoea in exercising men

CO2 rebreathing model in COPD: blood-to-gas equilibration

A new interpolation-free procedure for breath-by-breath analysis of oxygen uptake in exercise transients

Bronchodilator effect on ventilatory, pulmonary gas exchange, and heart rate kinetics during high-intensity exercise in COPD

Algorithms, modelling and $$ \dot{V}{\text{O}}_{ 2} $$ kinetics

Effect of sampling strategy on measures of V̇O2peak obtained using commercial breath-by-breath systems

New acquisitions in the assessment of breath-by-breath alveolar gas transfer in humans

Skeletal muscle ergoreflex overactivity is not related to exercise ventilatory inefficiency in non-hypoxaemic patients with COPD

Breath-by-breath fluctuations of pulmonary gas exchange and ventilation in COPD patients