NDLI: Skeletal muscle ergoreflex overactivity is not related to exercise ventilatory inefficiency in non-hypoxaemic patients with COPD

Content Provider	Springer Nature Link
Author	Nakamoto, Fernanda Patti Neder, J. Alberto Maia, Joyce Andrade, Marília S. Silva, Antônio Carlos
Copyright Year	2007
Abstract	Increased ventilatory response to the metabolic demand (“ventilatory inefficiency”) is commonly found during dynamic exercise in patients with chronic obstructive pulmonary disease (COPD). However, the role of enhanced muscle ergoreflex activity on this phenomenon is yet unknown. Ten non-hypoxaemic patients with varying degrees of disease severity (median and range of post-bronchodilator FEV1 = 37.5 (27 to 70%) predicted) and 7 age- and gender-matched controls were studied. Subjects were submitted to wrist flexion tests to the limit of tolerance (Tlim) with and without post-exercise regional circulatory occlusion (PE-RCO) for 3 min. The muscle ergoreflex activity was quantified as the difference in ventilation between PE-RCO and control recovery periods corrected for the resting values (ergoreflex Δ). In addition, the area under the ventilatory curve in the recovery period was calculated in both conditions. We found that Tlim and the physiological stress associated with localized exercise did not differ between patients and controls. However, patients had increased ventilatory response to a given metabolic demand $$({\dot{\rm V}}\hbox{CO}_2),$$ either at rest or during exercise (P < 0.05). There were no significant differences in ergoreflex Δ in patients and controls (−2.2 to 2.4 (0.2) vs. −0.6 to 1.8 (0.3) l/min, respectively). In addition, the area under the ventilatory curve in the recovery period did not differ between control and PE-RCO tests in patients and healthy subjects (P > 0.05). We conclude that increased muscle ergoreflex activity did not contribute to an excessive ventilatory response to exercise in patients with COPD—at least in non-hypoxaemic and non-cachetic subjects.
Starting Page	705
Ending Page	712
Page Count	8
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	101
Issue Number	6
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-08-25
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Ventilation Muscles Exercise COPD Ergoreflex Sports Medicine Occupational Medicine/Industrial Medicine Human Physiology
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Ventilatory responses to prolonged exercise with heavy load carriage

Skeletal muscle oxygen uptake in obese patients: functional evaluation by knee-extension exercise

Scaling skeletal muscle function to mass in patients with moderate-to-severe COPD

Effect of exercise-induced muscle damage on ventilatory and perceived exertion responses to moderate and severe intensity cycle exercise

Effects of mild-exercise training cessation in human skeletal muscle

New fundamental resistance exercise determinants of molecular and cellular muscle adaptations

Myogenic regulatory factor response to resistance exercise volume in skeletal muscle

Acute resistance exercise increases the expression of chemotactic factors within skeletal muscle

Estimation of the exercise ventilatory compensation point by the analysis of the relationship between minute ventilation and heart rate

Skeletal muscle ergoreflex overactivity is not related to exercise ventilatory inefficiency in non-hypoxaemic patients with COPD

Similar Documents

Ventilatory responses to prolonged exercise with heavy load carriage

Skeletal muscle oxygen uptake in obese patients: functional evaluation by knee-extension exercise

Scaling skeletal muscle function to mass in patients with moderate-to-severe COPD

Effect of exercise-induced muscle damage on ventilatory and perceived exertion responses to moderate and severe intensity cycle exercise

Effects of mild-exercise training cessation in human skeletal muscle

New fundamental resistance exercise determinants of molecular and cellular muscle adaptations

Myogenic regulatory factor response to resistance exercise volume in skeletal muscle

Acute resistance exercise increases the expression of chemotactic factors within skeletal muscle

Estimation of the exercise ventilatory compensation point by the analysis of the relationship between minute ventilation and heart rate

Skeletal muscle ergoreflex overactivity is not related to exercise ventilatory inefficiency in non-hypoxaemic patients with COPD