NDLI: Cerebral cortical blood flow in rabbits during parabolic flights (hypergravity and microgravity)

Content Provider	Springer Nature Link
Author	Florence, Geneviève Lemenn, Marc Desert, Sylvain Bourron, François Serra, André Bonnier, Richard Blanquie, Jean Pierre Charbonné, Robert Seylaz, Jacques
Copyright Year	1998
Abstract	We studied the effect of gravity on cerebral cortical blood flow (CBF), mean arterial blood pressure ( ) and heart rate in six rabbits exposed to parabolic flights. The CBF was obtained using a laser-Doppler probe fixed on to a cranial window. Before weightlessness, the animals were exposed to chest-to-back directed acceleration (1.8–2.0 g). The CBF values were expressed as a percentage of CBFo (mean CBF during 60 s before the 1st parabola). Propranolol (1 mg · kg−1 IV) was given after the 11th parabola and pentobarbital (12–15 mg · kg−1 IV) after the 16th parabola. Before the administration of the drugs, CBF increased (P < 0.01) during hypergravity [i.e. maximal CBF 151 (SD 64)% CBFo. Simultaneously increased [maximal , 119 (SD 11) mmHg (P < 0.01)]. At the onset of weightlessness, CBF and reached maximal values [194 (SD 96)% CBFo (P < 0.01) and 127 (SD 19) mmHg, (P < 0.01) respectively]. The microgravity-induced increase in CBF was transient since CBF returned to its baseline value after 8 (SD 2) s of microgravity. After propranolol administration, CBF was not statistically different during hypergravity but an elevation of CBF was still observed in weightlessness. The increases in CBF and also persisted during weightlessness after pentobarbital administration. These data would indicate that CBF of nonanesthetized rabbits increases during the first seconds of weightlessness and demonstrate the involvement of rapid active regulatory mechanisms since CBF returned to control values within 8 (SD 2) s. We concluded that this elevation in blood flow was not related to stress because it persisted after the administration of propranolol and pentobarbital.
Starting Page	469
Ending Page	478
Page Count	10
File Format	PDF
ISSN	03015548
Journal	European Journal of Applied Physiology
Volume Number	77
Issue Number	5
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	1998-03-23
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Physiology Public Health, Environmental and Occupational Health

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