NDLI: Ventilatory efficiency and exercise tolerance in 101 healthy volunteers

Content Provider	Springer Nature Link
Author	Habedank, D. Reindl, I. Vietzke, G. Bauer, U. Sperfeld, A. Gläser, S. Wernecke, K. D. Kleber, F. X.
Copyright Year	1998
Abstract	The ventilatory equivalent for CO2 defines ventilatory efficiency largely independent of metabolism. An impairment of ventilatory efficiency may be caused by an increase in either anatomical or physiological dead space, the latter being the most important mechanism in the hyperpnoea of heart failure, pulmonary embolism, pulmonary hypertension and the former in restrictive lung disease. However, normal values for ventilatory efficiency have not yet been established. We investigated 101 (56 men) healthy volunteers, aged 16–75 years, measuring ventilation and gas exchange at rest (n = 64) and on exercise (modified Naughton protocol, n = 101). Age and sex dependent normal values for ventilatory efficiency at rest defined as the ratio ventilation:carbon dioxide output (V˙ E:V˙CO2), exercise ventilatory efficiency during exercise, defined as the slope of the linear relationship between ventilation and carbon dioxide output (V˙ E vs V˙CO2 slope), oxygen uptake at the anaerobic threshold and at maximum (V˙O2AT,V˙O2max, respectively) and breathing reserve were established. Ventilatory efficiency at rest was largely independent of age, but was smaller in the men than in the women [V˙ E:V˙CO2 50.5 (SD 8.8) vs 57.6 (SD 12.6) P<0.05]. Ventilatory efficiency during exercise declined significantly with age and was smaller in the men than in the women (men: (V˙ E vs V˙CO2 slope = 0.13 × age + 19.9; women: V˙ E vs V˙CO2 slope = 0.12 × age + 24.4). The V˙O2AT and V˙O2max were 23 (SD 5) and 39 (SD 7) ml O2 · kg · min−1 in the men and 18 (SD 4) and 32 (SD 7) in the women, respectively, and declined significantly with age. The V˙O2AT was reached at 58 (SD 9)% V˙O2max. Breathing reserve at the end of exercise was 41% and was independent of sex and age. It was concluded from this study that ventilatory efficiency as well as peak oxygen uptake are age and sex dependent in adults.
Starting Page	421
Ending Page	426
Page Count	6
File Format	PDF
ISSN	03015548
Journal	European Journal of Applied Physiology
Volume Number	77
Issue Number	5
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	1998-03-23
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Physiology Public Health, Environmental and Occupational Health

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