NDLI: Sex-related differences in sweat gland cholinergic sensitivity exist irrespective of differences in aerobic capacity

Content Provider	Springer Nature Link
Author	Madeira, Luciana Gonçalves Fonseca, Michele Atalla Fonseca, Ivana Alice Teixeira Oliveira, Kenya Paula Freitas Passos, Renata Lane Machado Moreira, Christia Antônio Rodrigues, Luiz Oswaldo Carneiro
Copyright Year	2009
Abstract	Mechanisms accounting for sex-related differences in the sweat response remain to be elucidated. In the present study, we focused on differences in sweat gland cholinergic sensitivity between males and females. Since, males usually possess higher aerobic capacity than females, we investigated sweating in males and females grouped according to aerobic capacity $$ ({\dot{V}} {\text{O}}_{{2{\text{peak}}}})$$ . Forty-four subjects were assigned to four groups: males with higher (MH) and lower (ML), and females with higher (FH) and lower (FL) $$ {\dot{V}} {\text{O}}_{{2{\text{peak}}}}.$$ Forearm sweating was induced by iontophoretic administration (1.5 mA, 60 μA cm−2, 5 min) of pure water or varying concentrations of pilocarpine hydrochloride (0.125, 0.250, 0.5, 1.0 and 2.0%). Local sweat rate (absorbent paper) and the number of activated sweat glands (iodine impregnated paper) were computed. Maximal pilocarpine-induced sweat rate (SRmax) and the pilocarpine concentration which elicited 50% of maximal sweating response (K m) were calculated. Sweat rate and active gland density increased in response to greater doses of pilocarpine (p < 0.05). Inter-group differences were evident: SRmax was greatest for MH and lowest for FL (p < 0.05), but no significant differences were observed between ML and FH (p = 0.24). Higher SRmax were observed, within-sex, for those with greater aerobic capacity (p < 0.05). Furthermore, males’ K m values were higher than females’, indicating greater sweat gland affinity for pilocarpine even for groups having similar aerobic capacity (p < 0.05). In summary, we confirmed that the human sudomotor response is affected by aerobic capacity but, also, that sex-related differences in sweat gland cholinergic sensitivity exist and are not necessarily associated with the typical differences in $$ {\dot{V}} {\text{O}}_{{2{\text{peak}}}}$$ observed between sexes.
Starting Page	93
Ending Page	100
Page Count	8
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	109
Issue Number	1
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	2009-11-10
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Sex-related differences Thermoregulation Sweat Pilocarpine dose–response curve Cholinergic sensitivity Sports Medicine Occupational Medicine/Industrial Medicine Human Physiology
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

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