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| Content Provider | Springer Nature Link |
|---|---|
| Author | Hoso, Takayoshi Kamo, Ayumi Hakotani, Satoshi Minato, Kenji Ake, Haruka Taguchi, Yu Miya, Akiko Iseki, Takumi |
| Copyright Year | 2009 |
| Abstract | Regarding therapeutic hypothermia for human neonatal hyperthermic hypoxic–ischemic encephalopathy (HIE), we investigated the motor function of a neonatal hyperthermic HIE rat model, and also performed systemic hypothermia using the model. Forty-two neonatal Wistar rats at 7-days-old were used in this study. The left common carotid artery of 34 neonatal rats was ligated under isoflurane anesthesia. We also established a sham group (S group, n = 8). After 1-h recovery, all rats were exposed to 8% oxygen at an ambient temperature (T a) of 40°C for 15 min. Following insult, 16 rats were placed in a chamber at a T a of 30°C (H group) and the other 18 rats at a T a of 37°C after arterial ligation (N group), and all rats in the S group were placed in a chamber at a T a of 37°C for 12 h. A Rota-Rod test was performed involving all rats at 8 weeks old. The rod was rotated at 5, 5, and 7 rpm on three consecutive days, respectively. Rats in the N group stayed on the rotating rod for a significantly shorter period than those in S and H groups only on the second day of measurement. The width of the insulted hemisphere in N group rats was significantly smaller than those in S and H groups. There was no significant correlation between S and H groups regarding the motor function and anatomy. These results suggest that neonatal hyperthermic hypoxic–ischemic insult impairs the motor function, which may be rescued by systemic hypothermia after insult. |
| Starting Page | 35 |
| Ending Page | 39 |
| Page Count | 5 |
| File Format | |
| ISSN | 14396319 |
| Journal | European Journal of Applied Physiology |
| Volume Number | 109 |
| Issue Number | 1 |
| e-ISSN | 14396327 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2009-08-14 |
| Publisher Place | Berlin/Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Rat Neonate Hypoxic–ischemic encephalopathy Rota-Rod test Hypothermia Sports Medicine Occupational Medicine/Industrial Medicine Human Physiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science |
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