NDLI: Normo- and hypobaric hypoxia: are there any physiological differences?

Content Provider	Springer Nature Link
Author	Savourey, Gustave Launay, Jean Claude Besnard, Yves Guinet, Angélique Travers, Stéphane
Copyright Year	2003
Abstract	Since Bert (1878) and Barcroft (1925), studies on hypoxia are realized by lowering ambient O2 partial pressure (PO2) either by barometric pressure reduction (hypobaric hypoxia HH) or by lowering the O2 fraction (normobaric hypoxia NH). Today, a question is still debated: "are there any physiological differences between HH and NH for the same ambient PO2?" Since published studies are scarce and controversial, we submitted 18 subjects in a random order to a 40-min HH test and to a 40-min NH test at an ambient PO2 equal to 120 hPa (4500 m). Cardioventilatory variables [breathing frequency (f), tidal volume (V t), minute ventilation (V˙E), O2 and CO2 end-tidal fractions or pressures (FETO2 and FETCO2 or PETO2 and PETCO2 respectively), heart rate (HR) and O2 arterial saturation by pulse oxymetry (SpO2)] were measured throughout the tests. At the end of the tests, arterial blood samples were taken to measure arterial blood gases [O2 and CO2 arterial partial pressures (PaO2 and PaCO2), pH and O2 arterial saturation (SaO2)]. Results show that during HH compared to NH, f is greater (P≤0.001), V t and V˙E under BTPS conditions are lower (P≤0.05), and FETO2 and FETCO2 are higher (P≤0.05). However, PETO2 does not change during the last 25 min of the tests, and neither does PETCO2 throughout the tests. HR is higher (P≤0.05) and SpO2 lower (P≤0.05) in HH compared to NH. Arterial blood data reveal that hypoxemia, hypocapnia and blood alkalosis are greater in HH compared to NH and that SaO2 is lower (P≤0.05). It is concluded that the physiological responses of humans submitted to an acute hypoxia at a PO2 equal to 120 hPa differ according to the type of hypoxia. Compared to NH, HH leads to a greater hypoxemia, hypocapnia, blood alkalosis and a lower O2 arterial saturation. These physiological differences could be the consequence of an increase in dead space ventilation, probably related to the barometric pressure reduction, and could be grouped together under the term "the specific response to hypobaric hypoxia". Knowledge of this specific response could improve the comprehension, prevention and treatment of altitude illnesses in the future.
Starting Page	122
Ending Page	126
Page Count	5
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	89
Issue Number	2
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	2003-02-11
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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