NDLI: Muscle intracellular oxygenation during exercise: optimization for oxygen transport, metabolism, and adaptive change

Content Provider	Springer Nature Link
Author	Wagner, Peter D.
Copyright Year	2011
Abstract	Exercise is the example par excellence of the body functioning as a physiological system. Conventionally we think of the O2 transport process as a major manifestation of that system linking and integrating pulmonary, cardiovascular, hematological and skeletal muscular contributions to the task of getting O2 from the air to the mitochondria, and this process has been well described. However, exercise invokes system responses at levels additional to those of macroscopic O2 transport. One such set of responses appears to center on muscle intracellular PO2, which falls dramatically from rest to exercise. At rest, it approximates 4 kPa, but during heavy endurance exercise it falls to about 0.4–0.5 kPa, an amazingly low value for a tissue absolutely dependent on the continual supply of O2 to meet very high energy demands. One wonders why intracellular PO2 is allowed to fall to such levels. The proposed answer, to be presented in the review, is that a low intramyocyte PO2 is pivotal in: (a) optimizing oxygen’s own physiological transport, and (b) stimulating adaptive gene expression that, after translation, enables greater exercise capacity—all the while maintaining PO2 at levels sufficient to allow oxidative phosphorylation to operate sufficiently fast enough to support intense muscle contraction. Thus, during exercise, reductions of intracellular PO2 to less than 1% of that in the atmosphere enables an integrated response that fundamentally and simultaneously optimizes physiological, biochemical and molecular events that support not only the exercise as it happens but the adaptive changes to increase exercise capacity over the longer term.
Starting Page	1
Ending Page	8
Page Count	8
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	112
Issue Number	1
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-04-22
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cellular PO2 Exercise Muscle Magnetic resonance spectroscopy Oxygen transport Oxidative phosphorylation Occupational Medicine/Industrial Medicine Human Physiology Sports Medicine
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

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