NDLI: The effect of 18 h of simulated high altitude on left ventricular function

Content Provider	Springer Nature Link
Author	Kjaergaard, Jesper Snyder, Eric M. Hassager, Christian Olson, Thomas P. Oh, Jae K. Johnson, Bruce D.
Copyright Year	2006
Abstract	High altitude produces increased pulmonary capillary pressure by hypoxia induced pulmonary vasoconstriction. It is also possible that hypoxia results in mildly elevated left ventricular (LV) filling pressures that may contribute to the elevated capillary pressures. This study investigates the impact of simulated high altitude on global and regional echocardiographic measures of LV performance and filling pressure. Seventeen healthy individuals underwent transthoracic echocardiography, including tissue Doppler of the septal mitral annulus and basal segments before and after an 18-h overnight stay in a high altitude simulation tent with a FiO2 of 12%, simulating an altitude of approximately 4,000 m above sea level. In simulated high altitude, the ratio of early transmitral flow velocity to early myocardial relaxation velocity increased 22%, P < 0.001, and the Index of Myocardial Performance increased 30%, P < 0.01 due to an 58% increase in the isovolumic relaxation time (IVRT), P < 0.001. Simulated high altitude leads to a reduction in LV performance with an accompanying increase in markers of LV filling pressure. The significant changes in filling pattern and IVRT in the setting of normal and unchanged systolic function, indicates that hypoxia induces mild diastolic dysfunction in young healthy individuals.
Starting Page	411
Ending Page	418
Page Count	8
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	98
Issue Number	4
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-09-21
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hypoxia Cardiac function Diastole Sports Medicine Occupational Medicine/Industrial Medicine Human Physiology
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The effect of acute hypoxia on left ventricular function during exercise

Effects of acute hypoxia on postural and kinetic tremor

Abnormal blood flow in the sublingual microcirculation at high altitude

Progression of changes in left ventricular function during four days of simulated multi-stage cycling

Living high–training low: effect on erythropoiesis and aerobic performance in highly-trained swimmers

Time course of haemoglobin mass during 21 days live high:train low simulated altitude

Right ventricular function with hypoxic exercise: effects of sildenafil

Effect of hypobaric hypoxia on heart rate variability during exercise: a pilot field study

Effect of acute normobaric hypoxia on the ventilatory threshold

The effect of 18 h of simulated high altitude on left ventricular function

Similar Documents

The effect of acute hypoxia on left ventricular function during exercise

Effects of acute hypoxia on postural and kinetic tremor

Abnormal blood flow in the sublingual microcirculation at high altitude

Progression of changes in left ventricular function during four days of simulated multi-stage cycling

Living high–training low: effect on erythropoiesis and aerobic performance in highly-trained swimmers

Time course of haemoglobin mass during 21 days live high:train low simulated altitude

Right ventricular function with hypoxic exercise: effects of sildenafil

Effect of hypobaric hypoxia on heart rate variability during exercise: a pilot field study

Effect of acute normobaric hypoxia on the ventilatory threshold

The effect of 18 h of simulated high altitude on left ventricular function