NDLI: Right ventricular function with hypoxic exercise: effects of sildenafil

Content Provider	Springer Nature Link
Author	Kjaergaard, Jesper Snyder, Eric M. Hassager, Christian Olson, Thomas P. Oh, Jae K. Johnson, Bruce D. Frantz, Robert P.
Copyright Year	2007
Abstract	The effect of sildenafil on right ventricular contractility in hypoxic exercise is unknown, whereas reports have shown that sildenafil is associated with a smaller increase in pulmonary vascular resistance and right ventricular systolic pressure (RVSP) with exercise at high altitude. The present study evaluates the changes induced by controlled hypoxia on right ventricular pressure and performance with and without sildenafil administration. Tricuspid annular isovolumic acceleration (IVA) and annular velocities were measured in 14 healthy subjects at rest and after maximal exercise in a cross-over, double blind placebo controlled trial in three situations: normoxia, normobaric hypoxia with, and normobaric hypoxia without the administration of 100 mg sildenafil. RVSP, assessed by Doppler echocardiography, was determined from the peak tricuspid regurgitation pressure gradient. RVSP during rest increased from 26.9 ± 2.3 mmHg in normoxia to 37.8 ± 6.9 mmHg in hypoxia, p < 0.01; sildenafil administration reduced RVSP in hypoxia to 30.5 ± 5.6, p < 0.01. Compared to normoxia at rest, IVA increased similarly with peak exercise in normoxia and hypoxiasildenafil (by 2.37 and 1.90 m/s2, respectively), but the observed increase in IVA during exercise was smaller (0.86 m/s2, p < 0.05) in hypoxiaplacebo. Right ventricular contractility, as estimated by IVA at peak exercise is increased with the administration of sildenafil as compared to placebo, and is not different from the values seen during exercise in normoxia. This effect seems independent of the effect of sildenafil on RVSP.
Starting Page	87
Ending Page	95
Page Count	9
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	102
Issue Number	1
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-10-02
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hypoxia Pulmonary hypertension Sildenafil Phosphodiesterase-5 inhibition Right ventricular function Sports Medicine Occupational Medicine/Industrial Medicine Human Physiology
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

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