NDLI: Influence of exercise on the circulating levels and macrophage production of IL-1β and IFNγ affected by metabolic syndrome: an obese Zucker rat experimental animal model

Content Provider	Springer Nature Link
Author	Martin Cordero, L. Garcia, J. J. Giraldo, E. Fuente, M. Manso, R. Ortega, E.
Copyright Year	2009
Abstract	Regular physical activity is recognized as a non-pharmacological treatment of genetic obesity and type-II diabetes, and based on the “anti-inflammatory” effects of exercise, it has been also proposed for improving the “chronic low-grade inflammation” in metabolic syndrome (MS). The aim of the present work was to evaluate the effects of an habitual exercise program (running, 5 days/week for 35 min at 35 cm/s for 14 weeks) and of a bout of acute exercise (running, for 35 min at 35 cm/s) on MS-associated disorders in the pro-inflammatory cytokines IL-1β and IFNγ. The study was carried out on obese Zucker rats (fa/fa). The obese rats presented higher circulating concentrations and constitutive macrophage production (in the absence of antigenic stimulus) of IL-1β (but not of IFNγ). But their production of both IL-1β and IFNγ by lipopolysaccharide (LPS)-stimulated macrophages was lower than that of the control lean rats. Our protocol of exercise training did not modify the circulating concentration and constitutive macrophage release of either IL-1β or IFNγ in the obese rats, but increased the production of both cytokines by LPS-stimulated macrophages. The single bout of acute exercise only increased the release of IL-1β by the LPS-stimulated macrophages from obese rats, in both sedentary and trained animals. The results indicated that: (1) circulating levels and constitutive production of IL-1β by macrophages are deregulated in rats with MS, and (2) IL-1β and IFNγ production by macrophages in response to antigenic stimulus (LPS) is impaired in the obese animals, and this MS-associated disorder is improved by the program of habitual exercise training.
Starting Page	535
Ending Page	543
Page Count	9
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	107
Issue Number	5
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	2009-08-18
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Exercise Metabolic syndrome Obesity Inflammation Macrophages Zucker rats Sports Medicine Occupational Medicine/Industrial Medicine Human Physiology
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Influence of exercise on NA- and Hsp72-induced release of IFNγ by the peritoneal suspension of macrophages and lymphocytes from genetically obese Zucker rats

Effects of habitual exercise on the eHsp72-induced release of inflammatory cytokines by macrophages from obese Zucker rats.

Increase of adiponectin receptor gene expression by physical exercise in soleus muscle of obese Zucker rats

Effect of exercise on glutamine metabolism in macrophages of trained rats

Acute exercise increases circulating inflammatory markers in overweight and obese compared with lean subjects

Short-term exercise training improves aerobic capacity with no change in arterial function in obesity

Effect of obesity and metabolic syndrome on hypoxic vasodilation

Walking promotes metabolic and baroreflex sensitivity improvement in fructose-fed male rats

The effects of resistance exercise training on arterial stiffness in metabolic syndrome

Influence of exercise on the circulating levels and macrophage production of IL-1β and IFNγ affected by metabolic syndrome: an obese Zucker rat experimental animal model

Similar Documents

Influence of exercise on NA- and Hsp72-induced release of IFNγ by the peritoneal suspension of macrophages and lymphocytes from genetically obese Zucker rats

Effects of habitual exercise on the eHsp72-induced release of inflammatory cytokines by macrophages from obese Zucker rats.

Increase of adiponectin receptor gene expression by physical exercise in soleus muscle of obese Zucker rats

Effect of exercise on glutamine metabolism in macrophages of trained rats

Acute exercise increases circulating inflammatory markers in overweight and obese compared with lean subjects

Short-term exercise training improves aerobic capacity with no change in arterial function in obesity

Effect of obesity and metabolic syndrome on hypoxic vasodilation

Walking promotes metabolic and baroreflex sensitivity improvement in fructose-fed male rats

The effects of resistance exercise training on arterial stiffness in metabolic syndrome

Influence of exercise on the circulating levels and macrophage production of IL-1β and IFNγ affected by metabolic syndrome: an obese Zucker rat experimental animal model