NDLI: Effect of exercise on glutamine metabolism in macrophages of trained rats

Content Provider	Springer Nature Link
Author	Santos, Ronaldo Vagner Thomatieli Caperuto, Érico Chagas Mello, Marco Túlio Costa Rosa, Luis Fernando Bicudo Pereira
Copyright Year	2009
Abstract	This study investigated the effect of exercise on glutamine metabolism in macrophages of trained rats. Rats were divided into three groups: sedentary (SED); moderately trained (MOD) rats that were swim trained 1 h/day, 5 days/week for 6 weeks; and exhaustively trained (EXT) rats that were similarly trained as MOD for 5 weeks and, in the 6th week, trained in three 1-h sessions/day with 150 min of rest between sessions. The animals swam with a load equivalent to 5.5% of their body weight and were killed 1 h after the last exercise session. Cells were collected, and glutamine metabolism in macrophage and function were assayed. Exercise increased phagocytosis in MOD when compared to SED (34.48 ± 1.79 vs 15.21 ± 2.91%, P < 0.05); however, H2O2 production was higher in MOD (75.40 ± 3.48 nmol h × 105 cell−1) and EXT (79.20 ± 1.18 nmol h × 105 cell−1) in relation to SED (32.60 ± 2.51 nmol h × 105 cell−1, P < 0.05). Glutamine consumption increased in MOD and EXT (26.53 ± 3.62 and 19.82 ± 2.62 nmol h × 105 cell−1, respectively) relative to SED (6.72 ± 0.57 nmol h × 105 cell−1, P < 0.05). Aspartate increased in EXT (9.72 ± 1.14 nmol h × 105 cell−1) as compared to SED (1.10 ± 0.19 nmol h × 105 cell−1, P < 0.05). Glutamine decarboxylation was increased in MOD (12.10 ± 0.27 nmol h × 105 cell−1) and EXT (16.40 ± 2.17 nmol h × 105 cell−1) relative to SED (1.10 ± 0.06 nmol h × 105 cell−1, P < 0.05). This study suggests an increase in macrophage function post-exercise, which was supported by enhanced glutamine consumption and metabolism, and highlights the importance for glutamine after exercise.
Starting Page	309
Ending Page	315
Page Count	7
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	107
Issue Number	3
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	2009-07-17
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Macrophage Moderate exercise Glutamine Exhaustive training Macrophage function Sports Medicine Occupational Medicine/Industrial Medicine Human Physiology
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Moderate exercise increases the metabolism and immune function of lymphocytes in rats

Endurance training accelerates exhaustive exercise-induced mitochondrial DNA deletion and apoptosis of left ventricle myocardium in rats

Metabolomics investigation of exercise-modulated changes in metabolism in rat liver after exhaustive and endurance exercises

Neutrophil response of anaerobic jump trained diabetic rats

Acute hypoxic exercise does not alter post-exercise iron metabolism in moderately trained endurance athletes

Exercise training in rats impairs the replenishment of white adipose tissue after partial lipectomy

The effects of high-intensity exercise on skeletal muscle neutrophil myeloperoxidase in untrained and trained rats

Specific training improves skeletal muscle mitochondrial calcium homeostasis after eccentric exercise

Oxygen uptake kinetics in trained adolescent females

Effect of exercise on glutamine metabolism in macrophages of trained rats

Similar Documents

Moderate exercise increases the metabolism and immune function of lymphocytes in rats

Endurance training accelerates exhaustive exercise-induced mitochondrial DNA deletion and apoptosis of left ventricle myocardium in rats

Metabolomics investigation of exercise-modulated changes in metabolism in rat liver after exhaustive and endurance exercises

Neutrophil response of anaerobic jump trained diabetic rats

Acute hypoxic exercise does not alter post-exercise iron metabolism in moderately trained endurance athletes

Exercise training in rats impairs the replenishment of white adipose tissue after partial lipectomy

The effects of high-intensity exercise on skeletal muscle neutrophil myeloperoxidase in untrained and trained rats

Specific training improves skeletal muscle mitochondrial calcium homeostasis after eccentric exercise

Oxygen uptake kinetics in trained adolescent females

Effect of exercise on glutamine metabolism in macrophages of trained rats