NDLI: Hypovolemic men and women regulate blood pressure differently following exposure to artificial gravity

Content Provider	Springer Nature Link
Author	Evans, Joyce M. Ribeiro, L. Christine Moore, Fritz B. Wang, Siqi Zhang, Qingguang Kostas, Vladimir Ferguson, Conr R. Serrador, Jorge Falvo, Michael Stenger, Michael B. Goswami, Nandu Rask, Jon C. Smith, Jeffrey D. Knapp, Charles F.
Copyright Year	2015
Abstract	In addition to serious bone, vestibular, and muscle deterioration, space flight leads to cardiovascular dysfunction upon return to gravity. In seeking a countermeasure to space flight-induced orthostatic intolerance, we previ ously determined that exposure to artificial gravity (AG) training in a centrifuge improved orthostatic tolerance of ambulatory subjects. This protocol was more effective in men than women and more effective when subjects exercised.We now determine the orthostatic tolerance limit (OTL) of cardiovascularly deconditioned (furosemide) men and women on one day following 90 min of AG compared to a control day (90 min of head-down bed rest, HDBR).There were three major findings: a short bout of artificial gravity improved orthostatic tolerance of hypovolemic men (30 %) and women (22 %). Men and women demonstrated different mechanisms of cardiovascular regulation on AG and HDBR days; women maintained systolic blood pressure the same after HDBR and AG exposure while men’s systolic pressure dropped (11 ± 2.9 mmHg) after AG. Third, as presyncopal symptoms developed, men’s and women’s cardiac output and stroke volume dropped to the same level on both days, even though the OTL test lasted significantly longer on the AG day, indicating cardiac filling as a likely variable to trigger presyncope.(1) Even with gender differences, AG should be considered as a space flight countermeasure to be applied to astronauts before reentry into gravity, (2) men and women regulate blood pressure during an orthostatic stress differently following exposure to artificial gravity and (3) the trigger for presyncope may be cardiac filling.
Starting Page	2631
Ending Page	2640
Page Count	10
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	115
Issue Number	12
e-ISSN	14396327
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2015-10-05
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Orthostatic tolerance Cardiovascular deconditioning Centrifugation Cardiac output Stroke volume Heart rate Human Physiology Occupational Medicine/Industrial Medicine Sports Medicine
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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