NDLI: Smoking-induced increase in urinary cadmium levels among Japanese women

Content Provider	Springer Nature Link
Author	Ikeda, M. Moriguchi, J. Ezaki, T. Fukui, Y. Ukai, H. Okamoto, S. Shimbo, S. Sakurai, H.
Copyright Year	2005
Abstract	Objective: To examine if cigarette smoking will induce elevation in cadmium (Cd) in urine. Methods: Information on smoking habits, and urinary levels of cadmium (Cd-U), α1-microglobulin (α1-MG), β2-microglobulin (β2-MG), creatinine (CR or cr), and urine specific gravity (SG or sg) was cited from a combination of three previously established databases on adult Japanese women. After exclusion of those with unclear answers on smoking habits (412 cases), the combination (12,846 cases) gave 11,092, 1420 and 334 cases of never, current and former smokers, respectively, for present statistical analyses. Results: Multiple regression analyses taking Cd-U as a dependent variable and 11 regions of urine collection, age and smoking habits as independent variables showed that age and regions were powerful confounders in the analysis for the effects of smoking on Cd-U. To exclude the confounding effects, current and former smokers were paired with age- and region-matched never smoking controls in subsequent analyses. In addition, former smokers were paired with age- and region-matched current smokers. The comparison of the paired cases showed that Cd-U for current smokers was significantly higher than that for never smokers. The levels for former smokers were however not higher than the levels for never smokers. When classified by the number of cigarettes consumed per day, Cd-U for current smokers increased dependently to the number of cigarettes (about 0.09 μg/cigarette/day) with leveling off at 15 or more cigarettes. There was a subtle cigarette dose-dependent increase in α1-MG, but the increase was insignificant in case of β2-MG. Estimation of the amount of Cd absorbed due to cigarette smoking followed by comparison with the increase in Cd-U suggested that almost all Cd absorbed will be excreted into urine. Conclusions: Among currently smoking Japanese women, cadmium in urine increased in a manner dependent to the number of cigarettes consumed daily. Thus, smoking is a confounder of Cd-U evaluation even among the population with relatively high dietary Cd burden.
Starting Page	533
Ending Page	540
Page Count	8
File Format	PDF
ISSN	03400131
Journal	International Archives of Occupational and Environmental Health
Volume Number	78
Issue Number	7
e-ISSN	14321246
Language	English
Publisher	Springer-Verlag
Publisher Date	2005-07-05
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cadmium in urine α1-Microglobulin β2-Microglobulin Smoking Women
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Biological variations in cadmium, α1-microglobulin, β2-microglobulin and N-acetyl-β-d-glucosaminidase in adult women in a non-polluted area

Changes in tubular dysfunction marker levels in parallel with the levels of copper, rather than cadmium, in urine of middle-aged women in non-polluted areas

Cadmium and tubular dysfunction marker levels in urine of residents in non-polluted areas with natural abundance of cadmium in Japan

Bi-linear dose–response relationship in general populations with low-level cadmium exposures in non-polluted areas in Japan

Reproducibility of Urinary Cadmium, α1-Microglobulin, and β2-Microglobulin Levels in Health Screening of the General Population

Association of past diseases with levels of cadmium and tubular dysfunction markers in urine of adult women in non-polluted areas in Japan

Urinary α1-microglobulin excretion as biomarker of renal toxicity in trichloroethylene-exposed persons

Closer correlation of cadmium in urine than that of cadmium in blood with tubular dysfunction markers in urine among general women populations in Japan

Relation of child birth and breast-feeding burden with cadmium and tubular dysfunction marker levels in urine of adult women in non-polluted areas in Japan

Smoking-induced increase in urinary cadmium levels among Japanese women

Similar Documents

Biological variations in cadmium, α1-microglobulin, β2-microglobulin and N-acetyl-β-d-glucosaminidase in adult women in a non-polluted area

Changes in tubular dysfunction marker levels in parallel with the levels of copper, rather than cadmium, in urine of middle-aged women in non-polluted areas

Cadmium and tubular dysfunction marker levels in urine of residents in non-polluted areas with natural abundance of cadmium in Japan

Bi-linear dose–response relationship in general populations with low-level cadmium exposures in non-polluted areas in Japan

Reproducibility of Urinary Cadmium, α1-Microglobulin, and β2-Microglobulin Levels in Health Screening of the General Population

Association of past diseases with levels of cadmium and tubular dysfunction markers in urine of adult women in non-polluted areas in Japan

Urinary α1-microglobulin excretion as biomarker of renal toxicity in trichloroethylene-exposed persons

Closer correlation of cadmium in urine than that of cadmium in blood with tubular dysfunction markers in urine among general women populations in Japan

Relation of child birth and breast-feeding burden with cadmium and tubular dysfunction marker levels in urine of adult women in non-polluted areas in Japan

Smoking-induced increase in urinary cadmium levels among Japanese women